Interleukin-13 (IL-13) is a monomeric 17 kDa immunoregulatory cytokine that plays a key role in the pathogenesis of allergy, cancer, and tissue fibrosis. It is secreted by several helper T cell subsets, NK cells, mast cells, eosinophils, basophils, and visceral smooth muscle cells. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages (By similarity).
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
100 μg | ¥ 2,660 | 5日内发货 | ||
500 μg | ¥ 10,600 | 5日内发货 | ||
1 mg | ¥ 17,800 | 5日内发货 |
生物活性 | 1. Immobilized Human IL-13, His Tag at 5μg/ml (100μl/Well). Dose response curve for Human IL-13Ra1, hFc Tag with the EC50 of 4.7μg/ml determined by ELISA. 2. Human IL-13, His Tag immobilized on CM5 Chip can bind Human IL-13Ra1, hFc Tag with an affinity constant of 0.7μM as determined in a SPR assay. |
产品描述 | Interleukin-13 (IL-13) is a monomeric 17 kDa immunoregulatory cytokine that plays a key role in the pathogenesis of allergy, cancer, and tissue fibrosis. It is secreted by several helper T cell subsets, NK cells, mast cells, eosinophils, basophils, and visceral smooth muscle cells. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages (By similarity). |
种属 | Human |
表达系统 | HEK293 |
标签 | N-His-Avi |
蛋白编号 | AAK53823 |
别名 | NC30, ALRH, IL13, MGC116786, MGC116789, P600, MGC116788, BHR1, IL-13, interleukin 13 |
蛋白构建 | Recombinant Human IL-13 Protein is expressed from HEK293 with His tag and Avi tag at the N-Terminus. It contains Gly21-Asn132.[Accession |AAK53823] |
蛋白纯度 | > 90% as determined by Tris-Bis PAGE |
分子量 | The protein has a predicted MW of 15.3 kDa. Due to glycosylation, the protein migrates to 15 kDa and 25-45 kDa based on Tris-Bis PAGE result. |
内毒素 | Less than 1EU per μg by the LAL method. |
缓冲液 | Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
复溶方法 | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water. |
存储 |
-20 to -80°C for 12 months as supplied from date of receipt. -20 to -80°C for 3-6 months in unopened state after reconstitution. 2-8°C for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
运输方式 |
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. |
研究背景 | Interleukin-13 (IL-13) is a monomeric 17 kDa immunoregulatory cytokine that plays a key role in the pathogenesis of allergy, cancer, and tissue fibrosis. It is secreted by several helper T cell subsets, NK cells, mast cells, eosinophils, basophils, and visceral smooth muscle cells. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages (By similarity). |
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IL-13 Protein, Human, Recombinant (His & Avi) MGC-116788 NC30 IL 13 ALRH MGC 116786 MGC-116786 NC 30 IL13 MGC116786 MGC116789 P600 MGC 116788 MGC-116789 MGC116788 P 600 NC-30 BHR1 BHR 1 IL-13 P-600 MGC 116789 interleukin 13 BHR-1 recombinant recombinant-proteins proteins protein