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IL-36RN/IL-1F5 Protein, Human, Recombinant

产品编号 TMPY-00847

别名: IL1L1, IL1F5, FIL1, interleukin 36 receptor antagonist, FIL1(DELTA), FIL1(δ), IL-36Ra, PSORS14, FIL1D, IL36RA, IL36RN, PSORP, IL1RP3, IL1HY1

IL-36RN/IL-1F5 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.1 kDa and the accession number is Q9UBH0.

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IL-36RN/IL-1F5 Protein, Human, Recombinant

规格	价格/CNY		货期	数量
50 μg	￥ 2,940		5日内发货

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生物活性

技术参数

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参考文献

生物活性	Measured by its ability to inhibit IL36α-induced IL8 secretion in A431 human epithelial carcinoma cells. The ED50 for this effect is typically 0.1-0.4 μg/mL in the presence of 20ng/mL IL36α.
产品描述	IL-36RN/IL-1F5 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.1 kDa and the accession number is Q9UBH0.

种属	Human
表达系统	E. coli
标签	Tag Free
蛋白编号	Q9UBH0
别名	IL1L1, IL1F5, FIL1, interleukin 36 receptor antagonist, FIL1(DELTA), FIL1(δ), IL-36Ra, PSORS14, FIL1D, IL36RA, IL36RN, PSORP, IL1RP3, IL1HY1
蛋白构建	mature form of Human IL1F5 (Q9UBH0) (Met1-Asp155)
蛋白纯度	> 99 % as determined by SDS-PAGE
分子量	17.1 kDa (predicted)

内毒素	Please contact us for more information.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Interleukin-1 family member 5 (IL-1F5), also known as interleukin 36 receptor antagonist (IL36RA), is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). IL-1F5 is a highly and specific antagonist of the IL-1 receptor-related protein 2-mediated response to interleukin 1 family member 9 (IL1F9). IL-1F5 could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist, and interleukin-1 receptor type I (IL-1R1), which is present in epithelial barriers and takes part in the local inflammatory response. It has been proved that IL-1F5 induces IL-4 mRNA and protein expression in glia in vitro and enhances hippocampal expression of IL-4 following intracerebroventricular injection. The inhibitory effect of IL-1F5 on LPS-induced IL-1β is attenuated in cells from IL-4-defective mice. Experiment results suggest that IL-1F5 mediates anti-inflammatory effects through its ability to induce IL-4 production and that this is a consequence of its interaction with the orphan receptor, single Ig IL-1R-related molecule (SIGIRR)/TIR8, as the effects were not observed in SIGIRR-/- mice. In contrast to its effects in brain tissue, IL-1F5 did not attenuate LPS-induced changes, or up-regulated IL-4 in macrophages or dendritic cells, suggesting that the effect is confined to the brain.

参考文献

1. Nicklin MJ,et al. (1994) A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist genes. Genomics. 19 (2): 382-4. 2. Debets R,et al. (2001) Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2. J Immunol. 167 (3): 1440-6. 3. Costelloe C,et al. (2008) IL-1F5 mediates anti-inflammatory activity in the brain through induction of IL-4 following interaction with SIGIRR/TIR8. J Neurochem. 105(5): 1960-9.

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Keywords

IL-36RN/IL-1F5 Protein, Human, Recombinant FIL 1 IL1L1 IL1F5 FIL1 interleukin 36 receptor antagonist FIL1(DELTA) FIL1(δ) IL-36Ra FIL-1 PSORS14 PSORS 14 FIL1D PSORS-14 IL36RA IL36RN PSORP IL1RP3 IL1HY1 recombinant recombinant-proteins proteins protein

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