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IL-28B Protein, Mouse, Recombinant (His)

产品编号 TMPY-00454

别名: INF-λ, IFL-1, interferon, lambda 3, interferon, λ3, INF-lambda, Il28, INF-alpha, INF-α, Il28b, IL-28B

IL-28B Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21.1 kDa and the accession number is Q8CGK6.

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IL-28B Protein, Mouse, Recombinant (His)

规格	价格/CNY		货期	数量
50 μg	￥ 2,440		5日内发货
1 mg	￥ 22,400		5日内发货

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参考文献

生物活性	Measured in antiviral assay using HepG2 cells infected with vesicular stomatitis virus. The ED50 for this effect is typically 44.6-178.4 ng/mL.
产品描述	IL-28B Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21.1 kDa and the accession number is Q8CGK6.

种属	Mouse
表达系统	HEK293 Cells
标签	C-His
蛋白编号	Q8CGK6
别名	INF-λ, IFL-1, interferon, lambda 3, interferon, λ3, INF-lambda, Il28, INF-alpha, INF-α, Il28b, IL-28B
蛋白构建	The Mouse Ifnl3 (NP_796370.1) (Met1-Val193) was expressed with a polyhistidine tag at the C-terminus.
蛋白纯度	> 95 % as determined by SDS-PAGE
分子量	21.1 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Interleukin-28B (IL-28B) also known as Interferon lambda-3 and IFN-lambda-3, belongs to the type III interferon family of cytokines and are highly similar to IL-29. IL-28B belongs to the newly described interferon lambda (IFNλ) family of cytokines. IL-28B is a cytokine with immunomodulatory activity. It functions in Up-regulating MHC class I antigen expression. IL-28B displays potent antiviral activity and antitumor activity. This cytokine serves as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway. IL-28B, like IL-12, is capable of robustly enhancing adaptive immunity. Moreover, we describe for the first time how IL-28B reduces regulatory T-cell populations during DNA vaccination, whereas IL-12 increases this cellular subset. We also show that IL-28B, unlike IL-12, can increase the percentage of splenic CD8+ T cells in vaccinated animals and that these cells are more granular and have higher antigen-specific cytolytic degranulation compared with cells taken from animals that received IL-12 as an adjuvant.

参考文献

1. Ge D, et al.. (2009) Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature. 461(7262): 399-401. 2. Morrow MP, et al.. (2009) Comparative ability of IL-12 and IL-28B to regulate Treg populations and enhance adaptive cellular immunity. Blood. 113(23): 5868-77. 3. Sheppard P, et al.. (2003) IL-28, IL-29 and their class II cytokine receptor IL-28R. Nat Immunol. 4(1): 63-8.

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Keywords

IL-28B Protein, Mouse, Recombinant (His) IFL 1 INF-λ IFL-1 IFL1 interferon, lambda 3 interferon, λ3 INF-lambda Il28 INF-alpha INF-α Il28b IL-28B recombinant recombinant-proteins proteins protein

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

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