Interferon‑alpha/beta receptor 1 (IFN‑ alpha / beta R1), also known as IFNAR1, are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R. It interacts with STAT1 and STAT2, the interaction requires its phosphorylation at Tyr-466. It also interacts with FBXW11, the substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
10 μg | ¥ 820 | 5日内发货 | ||
50 μg | ¥ 2,480 | 5日内发货 | ||
500 μg | ¥ 12,100 | 5日内发货 | ||
1 mg | ¥ 17,400 | 5日内发货 |
产品描述 | Interferon‑alpha/beta receptor 1 (IFN‑ alpha / beta R1), also known as IFNAR1, are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R. It interacts with STAT1 and STAT2, the interaction requires its phosphorylation at Tyr-466. It also interacts with FBXW11, the substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex. |
种属 | Rhesus macaque |
表达系统 | Human Cells |
标签 | C-6His |
蛋白编号 | A0A7N9D7J0 |
别名 | IFN-al, CRF2-1, IFN-alpha/beta receptor 1, human interferon-α receptor (HuIFN-α-Rec)10IFRC, α-type antiviral protein, AVP, Cytokine receptor family 2 member 1, IFN-alpha/beta R1, 干扰素, beta-type antiviral protein, IFN-α/β receptor 1, IFN-α/β R1, Cytokine receptor class-II member 1, β-type antiviral protein, human interferon-alpha receptor (HuIFN-alpha-Rec)10IFRC, alpha-type antiviral protein |
氨基酸序列 | Ala25-Lys437 |
蛋白构建 | Recombinant Rhesus Macaque Interferon Alpha/Beta Receptor 1 is produced by our Mammalian expression system and the target gene encoding Ala25-Lys437 is expressed with a 6His tag at the C-terminus. |
蛋白纯度 | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
分子量 | 70-120 KDa, reducing conditions |
内毒素 | Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
缓冲液 | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
复溶方法 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
存储 |
Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
运输方式 |
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below. |
研究背景 | Interferon‑alpha/beta receptor 1 (IFN‑ alpha / beta R1), also known as IFNAR1, are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R. It interacts with STAT1 and STAT2, the interaction requires its phosphorylation at Tyr-466. It also interacts with FBXW11, the substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex. |
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IFNAR1 Protein, Rhesus macaque, Recombinant (His) IFN-al CRF2-1 b-type antiviral protein IFN-a/b R1 human interferon-a receptor (HuIFN-a-Rec)10IFRC IFN-alpha/beta receptor 1 human interferon-α receptor (HuIFN-α-Rec)10IFRC α-type antiviral protein AVP Cytokine receptor family 2 member 1 IFN-alpha/beta R1 干扰素 beta-type antiviral protein IFN-α/β receptor 1 IFN-α/β R1 Cytokine receptor class-II member 1 IFN-a/b receptor 1 a-type antiviral protein β-type antiviral protein human interferon-alpha receptor (HuIFN-alpha-Rec)10IFRC alpha-type antiviral protein recombinant recombinant-proteins proteins protein