IFN-α, a cytokine expressed in human islets from individuals affected by type 1 diabetes, plays a key role in the pathogenesis of diabetes by upregulating inflammation, endoplasmic reticulum (ER) stress and MHC class I overexpression, three hallmarks of islet histology in early type 1 diabetes.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
100 μg | ¥ 3,100 | 5日内发货 | ||
500 μg | ¥ 12,400 | 5日内发货 | ||
1 mg | ¥ 20,700 | 5日内发货 |
生物活性 | Human IFN alpha/beta R1, His Tag captured on CM5 Chip via anti-his antibody can bind Mouse IFN alpha 1, hFc Tag with an affinity constant of 11.96 nM as determined in SPR assay. |
产品描述 | IFN-α, a cytokine expressed in human islets from individuals affected by type 1 diabetes, plays a key role in the pathogenesis of diabetes by upregulating inflammation, endoplasmic reticulum (ER) stress and MHC class I overexpression, three hallmarks of islet histology in early type 1 diabetes. |
种属 | Mouse |
表达系统 | HEK293 |
标签 | C-hFc |
蛋白编号 | P01572 |
别名 | IFN-α-1/13, IFN alpha1, 干扰素, Interferon α-1/13, Interferon alpha-1/13, IFNalpha 1, Interferon α-D, IFNA1, IFNα1, IFN-alpha-1, IFN α1, LeIF D, IFN α 1, IFN-α-1, Interferon α1, IFN-alpha-1/13, Interferon alpha 1, Interferon alpha-D |
蛋白构建 | Recombinant Mouse IFN alpha 1 Protein is expressed from HEK293 with hFc tag at the C-Terminus. It contains Cys24-Lys189.[Accession |P01572] |
蛋白纯度 | > 95% as determined by Tris-Bis PAGE |
分子量 | The protein has a predicted MW of 45.88 kDa. Due to glycosylation, the protein migrates to 50-60 kDa based on Tris-Bis PAGE result. |
内毒素 | Less than 1EU per μg by the LAL method. |
缓冲液 | Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
复溶方法 | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water. |
存储 |
-20 to -80°C for 12 months as supplied from date of receipt. -20 to -80°C for 3-6 months in unopened state after reconstitution. 2-8°C for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
运输方式 |
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. |
研究背景 | IFN-α, a cytokine expressed in human islets from individuals affected by type 1 diabetes, plays a key role in the pathogenesis of diabetes by upregulating inflammation, endoplasmic reticulum (ER) stress and MHC class I overexpression, three hallmarks of islet histology in early type 1 diabetes. |
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IFN-alpha 1/IFNA1 Protein, Mouse, Recombinant (hFc) IFNA 1 IFN-α-1/13 IFN-a-1 IFN alpha1 干扰素 Interferon α-1/13 Interferon alpha-1/13 IFNalpha 1 Interferon α-D Interferon a-D IFNA1 Interferon a 1 IFNα1 IFN-alpha-1 IFN α1 LeIF D IFN-a-1/13 Interferon a-1/13 IFN α 1 Interferon α 1 IFN-α-1 IFNα 1 Interferon α1 IFNA-1 IFN-alpha-1/13 Interferon alpha 1 Interferon alpha-D recombinant recombinant-proteins proteins protein