HVEM Protein, Rhesus macaque, Recombinant (His)

HVEM Protein, Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 22-40 KDa and the accession number is F7GSW4.

规格	价格/CNY		数量
10 μg	￥ 540	5日内发货
50 μg	￥ 1,170	5日内发货
500 μg	￥ 5,250	5日内发货
1 mg	￥ 7,510	5日内发货

规格

价格/CNY

货期

数量

10 μg

￥ 540

5日内发货

50 μg

￥ 1,170

5日内发货

500 μg

￥ 5,250

5日内发货

1 mg

￥ 7,510

5日内发货

产品描述	HVEM Protein, Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 22-40 KDa and the accession number is F7GSW4.

种属	Rhesus macaque
表达系统	Human Cells
标签	C-6His
蛋白编号	F7GSW4
别名	TNFRSF14, HVEA, Tumor Necrosis Factor Receptor Superfamily Member 14, Herpes Virus Entry Mediator A, HVEM, Herpesvirus Entry Mediator A, Tumor Necrosis Factor Receptor-Like 2, CD270, TR2
氨基酸序列	Leu39-Val203
蛋白构建	Recombinant Rhesus Macaque TNF Receptor Superfamily Member 14 is produced by our Mammalian expression system and the target gene encoding Leu39-Val203 is expressed with a 6His tag at the C-terminus.
蛋白纯度	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
分子量	22-40 KDa, reducing conditions

内毒素	Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
缓冲液	Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
复溶方法	Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
存储	Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
运输方式	The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
研究背景	Herpesvirus entry mediator (HVEM) is a type I membrane protein in the TNF receptor superfamily, and it can both promote and inhibit T cell activity. HVEM is highly expressed on naïve CD4+ T cells, CD8+ T memory cells, regulatory T cells, dendritic cells, monocytes, and neutrophils. It functions as a receptor for BTLA, CD160, LIGHT/TNFSF14, and Lymphotoxin-alpha. Ligation of HVEM by LIGHT triggers T cell, monocyte, and neutrophil activation and contributes to Th1 inflammation and cardiac allograft rejection. In contrast, HVEM binding to CD160 or BTLA suppresses T cell and dendritic cell activation and dampens intestinal inflammation. HVEM enhances the development of CD8+ T cell memory and Treg function. It is additionally expressed on intestinal epithelial cells, where its binding by intraepithelial lymphocyte (IEL) expressed CD160 promotes epitheilal integrity and host defense. The herpesvirus envelope glycoprotein gD, which binds HVEM to initiate membrane fusion, can antagonize both BTLA and LIGHT binding.

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HVEM Protein, Rhesus macaque, Recombinant (His)

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