Alpha-Synuclein Protein,Human,Recombinant (H50Q) is expressed in E. coli expression system. The predicted molecular weight is 14.45 kDa and the accession number is P37840-1.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
100 μg | ¥ 1,890 | 5日内发货 | ||
1 mg | ¥ 12,300 | 5日内发货 |
生物活性 | Testing in progress |
产品描述 | Alpha-Synuclein Protein,Human,Recombinant (H50Q) is expressed in E. coli expression system. The predicted molecular weight is 14.45 kDa and the accession number is P37840-1. |
种属 | Human |
表达系统 | E. coli |
标签 | Tag Free |
蛋白编号 | P37840-1 |
别名 | Human α-Synuclein Protein (H50Q), synuclein, alpha (non A4 component of amyloid precursor), PARK1, PARK4, NACP, synuclein, α (non A4 component of amyloid precursor), PD1 |
蛋白构建 | A DNA sequence encoding the human SNCA (P37840-1) (H50Q, Met1-Ala140) was expressed. |
蛋白纯度 | ≥ 90 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC. |
分子量 | 14.45 kDa (predicted) |
内毒素 | < 1.0 EU per μg protein as determined by the LAL method. |
缓冲液 | Lyophilized from sterile PBS 2mM TCEP, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0. 01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA. |
复溶方法 | A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information. |
存储 |
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
运输方式 |
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. |
研究背景 | Alpha-Synuclein (alpha-Syn), also known as NACP or SNCA, exists as at least two structural isoforms: one is helix-rich, membrane-bound form that both the N- and C-terminal regions of alpha-synuclein are tightly associated with membranes and the other is disordered, cytosolic form. Synuclein is found predominantly in the presynaptic termini, in both free or membrane-bound forms. SNCA is extensively localized in nucleus of neurons. It has been shown that alpha-Synuclein was highly expressed in the mitochondria in olfactory bulb, hippocampus, striatum, and thalamus, where the cytosolic alpha-Synuclein was also rich. Normally the unstructured soluble type of alpha-synuclein can aggregate to form insoluble fibrils in pathological conditions characterized by Lewy bodies, such as Parkinson's disease, dementia with Lewy bodies and multiple system atrophy. SNCA abnormality and mitochondrial deficiency are two major changes in the brain of patients with Parkinson's disease (PD). Besides, alpha-synuclein is an abundant component of Lewy bodies in sporadic Parkinson's disease and diffuse Lewy body disease. |
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Alpha-Synuclein Protein,Human,Recombinant (H50Q) PARK-4 non A4 component of amyloid precursor PARK 1 PARK-1 PARK 4 Human α-Synuclein Protein (H50Q) PD-1 PD 1 synuclein, alpha (non A4 component of amyloid precursor) PARK1 synuclein, alpha PARK4 NACP synuclein, α (non A4 component of amyloid precursor) PD1 recombinant recombinant-proteins proteins protein