HLA-A*11:01&B2M&KRAS G12D (VVVGADGVGK) Monomer Protein, Human, MHC (His & Avi)

Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail.

规格	价格/CNY		货期	数量
100 μg	￥ 926	待询
1 mg	￥ 6,227	待询

规格

价格/CNY

货期

数量

100 μg

￥ 926

待询

1 mg

￥ 6,227

待询

生物活性	Human HLA-A11:01&B2M&KRAS G12D (VVVGADGVGK) Monomer, His Tag captured on CM5 Chip via Anti-His Antibody can bind HLA-A11:01&B2M&KRAS G12D (VVVGADGVGK) TCR with an affinity constant of 14.91 nM as determined in SPR assay (Biacore T200).
产品描述	Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail.

种属	Human
表达系统	HEK293
标签	C-His-Avi
蛋白编号	AAV53343.1(HLA-A*11:01)&P61769(B2M)&VVVGADGVGK
别名	K-RAS4A, KRAS1, MHC, K-RAS2B, CFC2, GTPase Kras, K-RAS4B, KRAS2, NS3, K-RAS2A, NS, K-Ras 2, KRAS, C-K-RAS, KI-RAS, RALD, RASK2
蛋白构建	Recombinant Human HLA-A11:01&B2M&KRAS G12D (VVVGADGVGK) Monomer Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus. It contains Gly25-Thr305(HLA-A11:01),Ile21-Met119(B2M) and VVVGADGVGK peptide.[Accession \|AAV53343.1(HLA-A*11:01)&P61769(B2M)&VVVGADGVGK]
蛋白纯度	> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC

内毒素	Less than 1EU per μg by the LAL method.
缓冲液	Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
复溶方法	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
存储	-20 to -80°C for 12 months as supplied from date of receipt.-20 to -80°C for 3-6 months in unopened state after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
运输方式	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
研究背景	Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail.