HER2/ErbB2 Protein, Human, Recombinant (His & Avi)

ErbB2, also called Neu and Her2 (human epidermal growth factor receptor 2), is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors. ErbB family members serve as receptors for the epidermal growth factor (EGF) family of growth factors.Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane.

规格	价格/CNY		数量
100 μg	￥ 2,960	5日内发货
500 μg	￥ 11,800	5日内发货
1 mg	￥ 19,700	5日内发货

规格

价格/CNY

货期

数量

100 μg

￥ 2,960

5日内发货

500 μg

￥ 11,800

5日内发货

1 mg

￥ 19,700

5日内发货

生物活性

Immobilized Human Her2, His Tag at 0.2μg/ml (100μl/well) on the plate. Dose response curve for Anti-Her2 Antibody, hFc Tag with the EC50 of 14.2ng/ml determined by ELISA.

产品描述

种属	Human
表达系统	HEK293
标签	C-His-Avi
蛋白编号	P04626-1
别名	MLN 19, HER2, HER-2, HERVW, EGFR2, ENV, ERBB2, NEU, HERV7Q, ERVWE1, ENVW, CD340, NGL, TKR1, herstatin, MLN19
蛋白构建	Recombinant Human Her2/ErbB2 Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus. It contains Thr23-Thr652.[Accession \|P04626-1]
蛋白纯度	> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
分子量	The protein has a predicted MW of 72.3 kDa. Due to glycosylation, the protein migrates to 80-100 kDa based on Tris-Bis PAGE result.

内毒素	Less than 1EU per μg by the LAL method.
缓冲液	Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
复溶方法	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
存储	-20 to -80°C for 12 months as supplied from date of receipt. -20 to -80°C for 3-6 months in unopened state after reconstitution. 2-8°C for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
运输方式	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
研究背景	ErbB2, also called Neu and Her2 (human epidermal growth factor receptor 2), is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors. ErbB family members serve as receptors for the epidermal growth factor (EGF) family of growth factors.Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane.