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GDF-5 Protein, Human, Recombinant

GDF-5 Protein, Human, Recombinant

产品编号 TMPJ-00966
别名: Lipopolysaccharide-associated protein 4, Cartilage-derived morphogenetic protein 1, Radotermin, LPS-associated protein 4, CDMP-1, LAP-4, Growth/differentiation factor 5, Bone morphogenetic protein 14, GDF-5, BMP-14, CDMP1

Growth Differentiation Factor 5(GDF-5, BMP-14) is a member of the BMP family of TGFβ superfamily proteins. Human GDF-5, -6, and -7 are a defined subgroup of the BMP family. GDF-5 is synthesized as a homodimeric precursor protein consisting of a 354 amino acid (aa) Nterminal proregion and a 120 aa C-terminal mature peptide. Mature human GDF-5 shares 99% aa sequence identity with both mature mouse and rat GDF-5. GDF-5 signaling is mediated by formation of a heterodimeric complex consisting of a type 1 (BMPR-IB) and a type II (BMPR-IIor Activin RII) serine/threonine kinase receptor which results in the phosphorylation and activation of cytosolic Smad proteins (Smad1, 5, and 8). GDF-5 is involved in multiple developmental processes including limb generation, cartilage development, joint formation, bone morphogenesis, cell survival, and neuritogenesis. Inhibition of GDF-5 expression or alteration of its signaling can facilitate the development of osteoarthritis.

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GDF-5 Protein, Human, Recombinant
规格 价格/CNY 货期 数量
10 μg ¥ 460 5日内发货
50 μg ¥ 1,410 5日内发货
500 μg ¥ 5,930 5日内发货
1 mg ¥ 9,490 5日内发货
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产品目录号及名称: GDF-5 Protein, Human, Recombinant (TMPJ-00966)
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产品性质
产品描述 Growth Differentiation Factor 5(GDF-5, BMP-14) is a member of the BMP family of TGFβ superfamily proteins. Human GDF-5, -6, and -7 are a defined subgroup of the BMP family. GDF-5 is synthesized as a homodimeric precursor protein consisting of a 354 amino acid (aa) Nterminal proregion and a 120 aa C-terminal mature peptide. Mature human GDF-5 shares 99% aa sequence identity with both mature mouse and rat GDF-5. GDF-5 signaling is mediated by formation of a heterodimeric complex consisting of a type 1 (BMPR-IB) and a type II (BMPR-IIor Activin RII) serine/threonine kinase receptor which results in the phosphorylation and activation of cytosolic Smad proteins (Smad1, 5, and 8). GDF-5 is involved in multiple developmental processes including limb generation, cartilage development, joint formation, bone morphogenesis, cell survival, and neuritogenesis. Inhibition of GDF-5 expression or alteration of its signaling can facilitate the development of osteoarthritis.
种属 Human
表达系统 E. coli
标签 None
蛋白编号 P43026
别名 Lipopolysaccharide-associated protein 4, Cartilage-derived morphogenetic protein 1, Radotermin, LPS-associated protein 4, CDMP-1, LAP-4, Growth/differentiation factor 5, Bone morphogenetic protein 14, GDF-5, BMP-14, CDMP1
氨基酸序列 Ala382-Arg501
蛋白构建 Recombinant Human Growth/Differentiation Factor 5 is produced by our E.coli expression system and the target gene encoding Ala382-Arg501 is expressed.
蛋白纯度 Greater than 90% as determined by reducing SDS-PAGE. (QC verified)
分子量 15 KDa, reducing conditions
内毒素 Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
缓冲液 Lyophilized from a 0.2 μm filtered solution of 4mM HCl.
复溶方法 Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in 4mM HCl. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 
存储

Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

运输方式

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.

研究背景 Growth Differentiation Factor 5(GDF-5, BMP-14) is a member of the BMP family of TGFβ superfamily proteins. Human GDF-5, -6, and -7 are a defined subgroup of the BMP family. GDF-5 is synthesized as a homodimeric precursor protein consisting of a 354 amino acid (aa) Nterminal proregion and a 120 aa C-terminal mature peptide. Mature human GDF-5 shares 99% aa sequence identity with both mature mouse and rat GDF-5. GDF-5 signaling is mediated by formation of a heterodimeric complex consisting of a type 1 (BMPR-IB) and a type II (BMPR-IIor Activin RII) serine/threonine kinase receptor which results in the phosphorylation and activation of cytosolic Smad proteins (Smad1, 5, and 8). GDF-5 is involved in multiple developmental processes including limb generation, cartilage development, joint formation, bone morphogenesis, cell survival, and neuritogenesis. Inhibition of GDF-5 expression or alteration of its signaling can facilitate the development of osteoarthritis.

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Keywords

GDF-5 Protein, Human, Recombinant Lipopolysaccharide-associated protein 4 Cartilage-derived morphogenetic protein 1 Radotermin LPS-associated protein 4 LAP 4 CDMP-1 GDF5 LAP4 LAP-4 Growth/differentiation factor 5 BMP 14 BMP14 Bone morphogenetic protein 14 GDF-5 CDMP 1 BMP-14 CDMP1 GDF 5 recombinant recombinant-proteins proteins protein

 

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