Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
100 μg | ¥ 6,670 | 5日内发货 | ||
500 μg | ¥ 26,700 | 5日内发货 | ||
1 mg | ¥ 44,500 | 5日内发货 |
生物活性 | Immobilized Human GFRAL, His Tag at 1μg/ml (100μl/Well) on the plate. Dose response curve for Biotinylated Human GDF15, hFc Tag with the EC50 of 4.2ng/ml determined by ELISA. |
产品描述 | Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. |
种属 | Human |
表达系统 | HEK293 |
标签 | N-hFc |
蛋白编号 | Q99988 |
别名 | MIC-1, PTGFBPTGF-β, GDF15, PTGF-β, GDF-15, PTGF-beta, Placental TGF-beta, PTGFBPTGF-beta, NAG-1, RG-1, Placental TGF-β, PDF, PLAB, PTGFB, MIC1 |
蛋白构建 | Recombinant Biotinylated Human GDF15 Protein (Primary Amine Labeling) is expressed from HEK293 with hFc tag at the N-Terminus. It contains Ala197-Ile308.[Accession |Q99988] |
蛋白纯度 | > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC |
分子量 | The protein has a predicted MW of 37.9 kDa. Due to glycosylation, the protein migrates to 40-50 kDa based on Tris-Bis PAGE result. |
内毒素 | Less than 1EU per μg by the LAL method. |
缓冲液 | Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
复溶方法 | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water. |
存储 |
-20 to -80°C for 12 months as supplied from date of receipt. -20 to -80°C for 3-6 months in unopened state after reconstitution. 2-8°C for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
运输方式 |
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. |
研究背景 | Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. |
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GDF-15 Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated RG1 Placental TGF-b GDF 15 PTGF-b MIC-1 PTGFBPTGF-β GDF15 PTGF-β MIC 1 NAG 1 RG 1 GDF-15 PTGF-beta Placental TGF-beta NAG1 PTGFBPTGF-b PTGFBPTGF-beta NAG-1 RG-1 Placental TGF-β PDF PLAB PTGFB MIC1 recombinant recombinant-proteins proteins protein