GDF-15 Protein (Primary Amine Labeling), Human, Recombinant (H202D, hFc), Biotinylated

Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance.

规格	价格/CNY		数量
100 μg	￥ 5,930	5日内发货
500 μg	￥ 23,700	5日内发货
1 mg	￥ 39,500	5日内发货

规格

价格/CNY

货期

数量

100 μg

￥ 5,930

5日内发货

500 μg

￥ 23,700

5日内发货

1 mg

￥ 39,500

5日内发货

生物活性

Immobilized Human GFRAL, His Tag at 0.5μg/ml (100μl/well) on the plate. Dose response curve for Biotinylated Human GDF15 (H202D), hFc Tag with the EC50 of 4.4ng/ml determined by ELISA.

产品描述

种属	Human
表达系统	HEK293
标签	N-hFc
蛋白编号	Q99988
别名	Placental TGF-β, GDF15, RG-1, MIC-1, PTGFB, PTGF-beta, PDF, PTGF-β, PTGFBPTGF-β, NAG-1, PTGFBPTGF-beta, PLAB, MIC1, GDF-15, Placental TGF-beta
蛋白构建	Recombinant Biotinylated Human GDF15 (H202D) Protein (Primary Amine Labeling) is expressed from HEK293 with hFc tag at the N-terminus. It contains Ala197-Ile308 (H202D).[Accession \|Q99988]
蛋白纯度	> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
分子量	The protein has a predicted MW of 37.88 kDa. Due to glycosylation, the protein migrates to 40-50 kDa based on Tris-Bis PAGE result.

内毒素	Less than 1EU per μg by the LAL method.
缓冲液	Supplied as 0.22 μm filtered solution in PBS (pH 7.4).
存储	Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
运输方式	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
研究背景	Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance.