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Galectin-1 Protein, Mouse, Recombinant

产品编号 TMPY-02102

别名: L-14.5, Galbp, AA410090, lectin, galactoside-binding, soluble, 1, galectin-1, L14, Lect14, Gal-1

Galectin-1 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15 kDa and the accession number is P16045.

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Galectin-1 Protein, Mouse, Recombinant

规格	价格/CNY		货期	数量
20 μg	￥ 1,350		5日内发货
100 μg	￥ 2,940		5日内发货
1 mg	￥ 14,800		5日内发货

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参考文献

生物活性	Measured by its ability to agglutinate human red blood cells. The ED50 for this effect is typically 6-60 μg/ml.
产品描述	Galectin-1 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15 kDa and the accession number is P16045.

种属	Mouse
表达系统	E. coli
标签	Tag Free
蛋白编号	P16045
别名	L-14.5, Galbp, AA410090, lectin, galactoside-binding, soluble, 1, galectin-1, L14, Lect14, Gal-1
蛋白构建	The Mouse Lgals1 (P16045) (Met 1-Glu 135) was expressed and purified.
蛋白纯度	> 95 % as determined by SDS-PAGE
分子量	15 kDa (predicted)

内毒素	Please contact us for more information.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Galectin-1 (Gal-1, GAL1), is a member of the galectins, a family of animal lectins ranging from Caenorhabditis elegans to humans, which is defined by their affinity for beta-galactosides and by significant sequence similarity in the carbohydrate-binding site. It is a homodimer with a subunit molecular mass of 14.5 kDa, which contains six cysteine residues per subunit. The cysteine residues should be in a free state to maintain a molecular structure that is capable of showing lectin activity. This endogenous lectin widely expressed at sites of inflammation and tumor growth has been postulated as an attractive immunosuppressive agent to restore immune cell tolerance and homeostasis in autoimmune and inflammatory settings. On the other hand, galectin-1 contributes to different steps of tumor progression including cell adhesion, migration, and tumor-immune escape, suggesting that blockade of galectin-1 might result in therapeutic benefits in cancer. Several potential glycoprotein ligands for galectin-1 have been identified, including lysosome-associated membrane glycoproteins and fibronectin, laminin, as well as T-cell glycoproteins CD43 and CD45. Evidence points to Gal-1 and its ligands as one of the master regulators of such immune responses as T-cell homeostasis and survival, T-cell immune disorders, inflammation, and allergies as well as host-pathogen interactions.

参考文献

1. Gaudet AD, et al. (2005) Expression and functions of galectin-1 in sensory and motoneurons. Curr Drug Targets. 6(4): 419-25. 2. Kadoya T, et al. (2006) Structural and functional studies of galectin-1: a novel axonal regeneration-promoting activity for oxidized galectin-Curr Drug Targets. 6(4): 375-83. 3. Camby I, et al. (2006) Galectin-1: a small protein with major functions. Glycobiology. 16(11): 137R-157R. 4. Salatino M, et al. (2008) Galectin-1 as a potential therapeutic target in autoimmune disorders and cancer. Expert Opin Biol Ther. 8(1): 45-57.

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Keywords

Galectin-1 Protein, Mouse, Recombinant L-14.5 Galbp AA-410090 AA410090 L-14 lectin, galactoside-binding, soluble, 1 galectin-1 L14 Lect14 L 14 AA 410090 Gal-1 recombinant recombinant-proteins proteins protein

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