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ENSA Protein, Human, Recombinant (His)

产品编号 TMPY-03411

别名: endosulfine alpha, endosulfine α, ARPP-19e

ENSA Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 15.2 kDa and the accession number is O43768-1.

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ENSA Protein, Human, Recombinant (His)

规格	价格/CNY		货期	数量
100 μg	￥ 2,530		5日内发货

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参考文献

生物活性	Testing in progress
产品描述	ENSA Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 15.2 kDa and the accession number is O43768-1.

种属	Human
表达系统	E. coli
标签	His
蛋白编号	O43768-1
别名	endosulfine alpha, endosulfine α, ARPP-19e
蛋白构建	A DNA sequence encoding the mature form of human ENSA (O43768-1) (Met1-Glu121) was expressed with a polyhistide tag at the N-terminus.
蛋白纯度	> 90 % as determined by SDS-PAGE
分子量	15.2 kDa (predicted)

内毒素	Please contact us for more information.
缓冲液	Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0. 01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
复溶方法	A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information.
存储	Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
运输方式	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
研究背景	Endosulfine alpha, also known as ENSA, belongs to the endosulfine family. It is a highly conserved cAMP-regulated phosphoprotein (ARPP) family. Endosulfine alpha is widely expressed with high levels in skeletal muscle and brain and lower levels in the pancreas. As a protein phosphatase inhibitor, ENSA specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase By similarity. Endosulfine alpha also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents.

参考文献

1. Ye M. et al., 2001, Genome Res. 10 (10): 1546-60. 2. Apiou F. et al., 1999, Diabetes 48 (9): 1873-6. 3. Lennon G. et al., 1997, Genome Res. 6 (9): 791-806.

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Keywords

ENSA Protein, Human, Recombinant (His) endosulfine alpha endosulfine α ARPP-19e recombinant recombinant-proteins proteins protein

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