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DR4/TRAIL R1 Protein, Human, Recombinant (hFc)

DR4/TRAIL R1 Protein, Human, Recombinant (hFc)

产品编号 TMPY-01719
别名: TRAILR1, tumor necrosis factor receptor superfamily member 10a, DR4, TNFRSF10A, CD261, APO2, MGC9365, TRAILR-1

DR4/TRAIL R1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 41.3 kDa and the accession number is O00220.

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DR4/TRAIL R1 Protein, Human, Recombinant (hFc)
规格 价格/CNY 货期 数量
100 μg ¥ 2,530 5日内发货
1 mg ¥ 20,800 5日内发货
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产品目录号及名称: DR4/TRAIL R1 Protein, Human, Recombinant (hFc) (TMPY-01719)
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生物活性 Testing in progress
产品描述 DR4/TRAIL R1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 41.3 kDa and the accession number is O00220.
种属 Human
表达系统 HEK293
标签 hFc
蛋白编号 O00220
别名 TRAILR1, tumor necrosis factor receptor superfamily member 10a, DR4, TNFRSF10A, CD261, APO2, MGC9365, TRAILR-1
蛋白构建 A DNA sequence encoding the human TNFRSF10A (NP_003835.2) extracellular domain (Met 1-Asn 239) was fused with the Fc region of human IgG1 at the C-terminus.
蛋白纯度 > 92 % as determined by SDS-PAGE
分子量 41.3 kDa (predicted)
内毒素 < 1.0 EU per μg of the protein as determined by the LAL method
缓冲液 Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0. 01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
复溶方法 A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information.
存储

Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

运输方式

In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.

研究背景 Tumor necrosis factor receptor superfamily, member 10a (TRAIL R1), also known as TRAIL receptor 1 (TRAIL R1) or CD261 antigen, is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. TRAIL R1/CD261/TNFRSF10A serves as a receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TRAIL R1 can promote the activation of NF-kappa-B. TRAIL R1/CD261/TNFRSF10A induces apoptosis of many transformed cell lines but not of normal tissues, even though its death domain-containing receptor, DR4, is expressed on both cell types.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

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Keywords

DR4/TRAIL R1 Protein, Human, Recombinant (hFc) TRAILR1 APO 2 CD 261 tumor necrosis factor receptor superfamily member 10a MGC-9365 DR4 DR 4 DR-4 TNFRSF10A MGC 9365 CD261 APO2 MGC9365 CD-261 TRAILR 1 TRAILR-1 APO-2 recombinant recombinant-proteins proteins protein

 

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