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DHX36 Protein, Human, Recombinant (His & Myc)

产品编号 TMPH-00973

别名: DEAH-box protein 36, G4R1, ATP-dependent DNA/RNA helicase DHX36, DHX36, DEAD/H box polypeptide 36, DDX36, MLE-like protein 1, KIAA1488, MLEL1, RNA helicase associated with AU-rich element protein, G4-resolvase-1, RHAU

DHX36 Protein, Human, Recombinant (His & Myc) is expressed in E. coli.

TargetMol的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

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DHX36 Protein, Human, Recombinant (His & Myc)

规格	价格/CNY		货期	数量
20 μg	￥ 1,800		20日内发货
100 μg	￥ 3,420		20日内发货
1 mg	￥ 14,600		20日内发货

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产品性质

产品描述	DHX36 Protein, Human, Recombinant (His & Myc) is expressed in E. coli.

种属	Human
表达系统	E. coli
标签	N-terminal 10xHis-tagged and C-terminal Myc-tagged
蛋白编号	Q9H2U1
别名	DEAH-box protein 36, G4R1, ATP-dependent DNA/RNA helicase DHX36, DHX36, DEAD/H box polypeptide 36, DDX36, MLE-like protein 1, KIAA1488, MLEL1, RNA helicase associated with AU-rich element protein, G4-resolvase-1, RHAU
氨基酸序列	ERREEQIVQLLNSVQAKNDKESEAQISWFAPEDHGYGTEVSTKNTPCSENKLDIQEKKLINQEKKMFRIRNRSYIDRDSEYLLQENEPDGT Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
蛋白构建	89-179 aa
蛋白纯度	> 90% as determined by SDS-PAGE.
分子量	18.2 kDa (predicted)

缓冲液	If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
复溶方法	A hardcopy of COA with reconstitution instructions is sent along with the products. Please refer to it for detailed information.
存储	Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
运输方式	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
研究背景	Multifunctional ATP-dependent helicase that unwinds G-quadruplex (G4) structures. Plays a role in many biological processes such as genomic integrity, gene expression regulations and as a sensor to initiate antiviral responses. G4 structures correspond to helical structures containing guanine tetrads. Binds with high affinity to and unwinds G4 structures that are formed in nucleic acids (G4-ADN and G4-RNA). Plays a role in genomic integrity. Converts the G4-RNA structure present in telomerase RNA template component (TREC) into a double-stranded RNA to promote P1 helix formation that acts as a template boundary ensuring accurate reverse transcription. Plays a role in transcriptional regulation. Resolves G4-DNA structures in promoters of genes, such as YY1, KIT/c-kit and ALPL and positively regulates their expression. Plays a role in post-transcriptional regulation. Unwinds a G4-RNA structure located in the 3'-UTR polyadenylation site of the pre-mRNA TP53 and stimulates TP53 pre-mRNA 3'-end processing in response to ultraviolet (UV)-induced DNA damage. Binds to the precursor-microRNA-134 (pre-miR-134) terminal loop and regulates its transport into the synapto-dendritic compartment. Involved in the pre-miR-134-dependent inhibition of target gene expression and the control of dendritic spine size. Plays a role in the regulation of cytoplasmic mRNA translation and mRNA stability. Binds to both G4-RNA structures and alternative non-quadruplex-forming sequence within the 3'-UTR of the PITX1 mRNA regulating negatively PITX1 protein expression. Binds to both G4-RNA structure in the 5'-UTR and AU-rich elements (AREs) localized in the 3'-UTR of NKX2-5 mRNA to either stimulate protein translation or induce mRNA decay in an ELAVL1-dependent manner, respectively. Binds also to ARE sequences present in several mRNAs mediating exosome-mediated 3'-5' mRNA degradation. Involved in cytoplasmic urokinase-type plasminogen activator (uPA) mRNA decay. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines via the adapter molecule TICAM1. Required for early embryonic development and hematopoiesis. Involved in the regulation of cardioblast differentiation and proliferation during heart development. Involved in spermatogonia differentiation. May play a role in ossification.

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Keywords

DHX36 Protein, Human, Recombinant (His & Myc) DEAH-box protein 36 G4R1 ATP-dependent DNA/RNA helicase DHX36 DHX36 DEAD/H box polypeptide 36 DDX36 MLE-like protein 1 KIAA1488 MLEL1 RNA helicase associated with AU-rich element protein G4-resolvase-1 RHAU recombinant recombinant-proteins proteins protein

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

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