Claudin-18.1 Protein, Human, Recombinant (His)

Claudin-18(CLDN18) is a protein that in humans is encoded by the CLDN18 gene. It belongs to the group of claudins. CLDN18 belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells. CLDN18 plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. CLDN18 has two isoform A1 and isoform A2. IMAB362 (Claudiximab) is a monoclonal antibody against isoform 2 of Claudin-18. It is under investigation for the treatment of gastrointestinal adenocarcinomas and pancreatic tumors. IMAB362 was developed by Ganymed Pharmaceuticals AG.

规格	价格/CNY		数量
10 μg	￥ 1,970	5日内发货
50 μg	￥ 4,260	5日内发货
500 μg	￥ 17,400	5日内发货
1 mg	￥ 27,800	5日内发货

规格

价格/CNY

货期

数量

10 μg

￥ 1,970

5日内发货

50 μg

￥ 4,260

5日内发货

500 μg

￥ 17,400

5日内发货

1 mg

￥ 27,800

5日内发货

产品描述

种属	Human
表达系统	E. coli
标签	N-8His
蛋白编号	P56856
别名	CLDN18, Claudin-18
氨基酸序列	Asp28-Leu76
蛋白构建	Recombinant Human CLDN18.1 is produced by our E.coli expression system and the target gene encoding Asp28-Leu76 is expressed with a 8His tag at the N-terminus.
蛋白纯度	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
分子量	18 KDa, reducing conditions

内毒素	Less than 1 EU/µg as determined by LAL test.
缓冲液	Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 8% Sucrose, 2% Glycine, 20% Glycerol, 5mM DTT, 0.05% Tween 80, pH 8.0.
存储	Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.
运输方式	The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below.
研究背景	Claudin-18(CLDN18) is a protein that in humans is encoded by the CLDN18 gene. It belongs to the group of claudins. CLDN18 belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells. CLDN18 plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. CLDN18 has two isoform A1 and isoform A2. IMAB362 (Claudiximab) is a monoclonal antibody against isoform 2 of Claudin-18. It is under investigation for the treatment of gastrointestinal adenocarcinomas and pancreatic tumors. IMAB362 was developed by Ganymed Pharmaceuticals AG.

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Claudin-18.1 Protein, Human, Recombinant (His)

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