Claudin-18 Protein, Human, Recombinant (CLDN18.2), Fluorescent

Claudin-18 Protein, Human, Recombinant (CLDN18.2), Fluorescent is expressed in HEK293 mammalian cells. The predicted molecular weight is 54.74 kDa and the accession number is P56856-2.

规格	价格/CNY		数量
20 μg	￥ 6,390	5日内发货
100 μg	￥ 13,400	5日内发货
500 μg	￥ 47,400	5日内发货

规格

价格/CNY

货期

数量

20 μg

￥ 6,390

5日内发货

100 μg

￥ 13,400

5日内发货

500 μg

￥ 47,400

5日内发货

生物活性	Immobilized Human Claudin18.2-VLP (Full Length) Protein, Fluorescent at 5 μg/mL (100 μL/well) can bind Anti-Human claudin18.2 Antibody, Human IgG1, the EC50 is 53.9 ng/mL (QC tested).
产品描述	Claudin-18 Protein, Human, Recombinant (CLDN18.2), Fluorescent is expressed in HEK293 mammalian cells. The predicted molecular weight is 54.74 kDa and the accession number is P56856-2.

种属	Human
表达系统	HEK293
标签	Tag Free
蛋白编号	P56856-2
别名	SFTPJ, claudin 18, SFTA5
蛋白构建	A DNA sequence encoding the human CLDN18 (P56856-2) (Met1-Val261) was expressed. This protein carries a GFP tag.
分子量	54.74 kDa (predicted)

内毒素	< 1.0 EU per μg protein as determined by the LAL method.
缓冲液	Supplied as sterile 50mM Hepes, 150mM NaCl, 10% Trehalose, pH 7.2. Please contact us for any concerns or special requirements. Please refer to the specific buffer information in the hard copy of CoA.
存储	Samples are stable for up to twelve months from date of receipt at -70℃. Store it under sterile conditions at -70℃ or lower. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
运输方式	It is supplied and shipped as Solution with dry ice.
研究背景	Claudins family member Claudin18 (CLDN18) is a four-pass transmembrane protein with two extracellular loops and cytoplasmic N- and C-tails found in tight junctions. CLDN18 modulates paracellular permeability, polarity, and signaling. CLDN18 deficiency has been associated with atrophic gastritis, spasmolytic polypeptide-expressing metaplasia (SPEM), and asthma. Lung-specific CLDN18.1 modulates alveolar epithelial type II (AT2) cell proliferation and organ size. Restoration of CLDN18.1 expression in human lung cancer cells has been shown to suppress proliferation, inhibiting the IGF-1R/AKT axes. Not expressed in other healthy tissues, gastric mucosa-specific isoform CLDN18.2 expression manifests in primary gastric cancers. CLDN18.2 at the surface of epithelial tumor cells is a target in antibody and CAR-therapies currently in development.

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Claudin-18 Protein, Human, Recombinant (CLDN18.2), Fluorescent

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