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CDK7 Protein, Human, Recombinant (His)

产品编号 TMPH-01172

别名: 39 kDa protein kinase, Cyclin-dependent kinase 7, CDK-activating kinase 1, TFIIH basal transcription factor complex kinase subunit, CAK, p39 Mo15, MO15, STK1, CAK1, CDKN7, Serine/threonine-protein kinase 1, CDK7, Cell division protein kinase 7

CDK7 Protein, Human, Recombinant (His) is expressed in Baculovirus.

TargetMol的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

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CDK7 Protein, Human, Recombinant (His)

规格	价格/CNY		货期	数量
20 μg	￥ 2,360		20日内发货
100 μg	￥ 6,640		20日内发货
500 μg	￥ 9,490		20日内发货

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产品描述	CDK7 Protein, Human, Recombinant (His) is expressed in Baculovirus.

种属	Human
表达系统	Baculovirus
标签	N-terminal 10xHis-tagged
蛋白编号	P50613
别名	39 kDa protein kinase, Cyclin-dependent kinase 7, CDK-activating kinase 1, TFIIH basal transcription factor complex kinase subunit, CAK, p39 Mo15, MO15, STK1, CAK1, CDKN7, Serine/threonine-protein kinase 1, CDK7, Cell division protein kinase 7
氨基酸序列	MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
蛋白构建	1-346 aa
蛋白纯度	> 85% as determined by SDS-PAGE.
分子量	41.5 kDa as predicted

缓冲液	If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
复溶方法	A hardcopy of COA with reconstitution instructions is sent along with the products. Please refer to it for detailed information.
存储	Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
运输方式	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
研究背景	Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation). CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, thus regulating cell cycle progression. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Phosphorylation of POLR2A in complex with DNA promotes transcription initiation by triggering dissociation from DNA. Its expression and activity are constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 activation by phosphorylation, but is inactivated in turn by p53/TP53; this feedback loop may lead to an arrest of the cell cycle and of the transcription, helping in cell recovery, or to apoptosis. Required for DNA-bound peptides-mediated transcription and cellular growth inhibition.

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Keywords

CDK7 Protein, Human, Recombinant (His) 39 kDa protein kinase Cyclin-dependent kinase 7 CDK-activating kinase 1 TFIIH basal transcription factor complex kinase subunit CAK p39 Mo15 MO15 STK1 CAK1 CDKN7 Serine/threonine-protein kinase 1 CDK7 Cell division protein kinase 7 recombinant recombinant-proteins proteins protein

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

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