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CDK4 Protein, Human, Recombinant (His)

产品编号 TMPH-01169

别名: Cyclin-dependent kinase 4, CDK4, Cell division protein kinase 4, PSK-J3

CDK4 Protein, Human, Recombinant (His) is expressed in E. coli.

TargetMol的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

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CDK4 Protein, Human, Recombinant (His)

规格	价格/CNY		货期	数量
20 μg	￥ 1,320		20日内发货
100 μg	￥ 2,470		20日内发货
1 mg	￥ 10,700		20日内发货

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产品性质

产品描述	CDK4 Protein, Human, Recombinant (His) is expressed in E. coli.

种属	Human
表达系统	E. coli
标签	N-terminal 6xHis-tagged
蛋白编号	P11802
别名	Cyclin-dependent kinase 4, CDK4, Cell division protein kinase 4, PSK-J3
氨基酸序列	ATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
蛋白构建	2-303 aa
蛋白纯度	> 90% as determined by SDS-PAGE.
分子量	37.6 kDa (predicted)

缓冲液	Tris-based buffer,50% glycerol
复溶方法	A hardcopy of COA with reconstitution instructions is sent along with the products. Please refer to it for detailed information.
存储	Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
运输方式	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
研究背景	Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

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Keywords

CDK4 Protein, Human, Recombinant (His) Cyclin-dependent kinase 4 CDK4 Cell division protein kinase 4 PSK-J3 recombinant recombinant-proteins proteins protein

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

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