Tumor metastasis depends on the dynamic regulation of cell adhesion through β1-integrin. The Cub-Domain Containing Protein-1, CDCP1, is a transmembrane glycoprotein which regulates cell adhesion. Overexpression and loss of CDCP1 have been observed in the same cancer types to promote metastatic progression.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
100 μg | ¥ 3,550 | 5日内发货 | ||
500 μg | ¥ 14,200 | 5日内发货 | ||
1 mg | ¥ 23,700 | 5日内发货 |
生物活性 | Immobilized Human CDCP1, hFc Tag at 2μg/ml (100μl/Well) on the plate. Dose response curve for Biotinylated Anti-CDCP1 Antibody, hFc Tag with the EC50 of 15.5ng/ml determined by ELISA. |
产品描述 | Tumor metastasis depends on the dynamic regulation of cell adhesion through β1-integrin. The Cub-Domain Containing Protein-1, CDCP1, is a transmembrane glycoprotein which regulates cell adhesion. Overexpression and loss of CDCP1 have been observed in the same cancer types to promote metastatic progression. |
种属 | Human |
表达系统 | HEK293 |
标签 | C-hFc |
蛋白编号 | Q9H5V8-1 |
别名 | CDCP1, PRO5773, TRASK, UNQ2486, SIMA135, CD318 |
蛋白构建 | Recombinant Human CDCP1 Protein is expressed from HEK293 with hFc tag at the C-Terminus. It contains Phe30-Leu666.[Accession |Q9H5V8-1] |
蛋白纯度 | > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC |
分子量 | The protein has a predicted MW of 98.4 kDa. Due to glycosylation, the protein migrates to 115-130 kDa based on Tris-Bis PAGE result. |
内毒素 | Less than 1EU per μg by the LAL method. |
缓冲液 | Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
复溶方法 | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water. |
存储 |
-20 to -80°C for 12 months as supplied from date of receipt. -20 to -80°C for 3-6 months in unopened state after reconstitution. 2-8°C for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
运输方式 |
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. |
研究背景 | Tumor metastasis depends on the dynamic regulation of cell adhesion through β1-integrin. The Cub-Domain Containing Protein-1, CDCP1, is a transmembrane glycoprotein which regulates cell adhesion. Overexpression and loss of CDCP1 have been observed in the same cancer types to promote metastatic progression. |
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CDCP1 Protein, Human, Recombinant (hFc) CD 318 CDCP1 UNQ 2486 SIMA-135 PRO5773 SIMA 135 CD-318 CDCP-1 CDCP 1 UNQ-2486 PRO-5773 PRO 5773 TRASK UNQ2486 SIMA135 CD318 recombinant recombinant-proteins proteins protein