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BCAM Protein, Mouse, Recombinant (hFc)

产品编号 TMPY-02455

别名: 1200005K12Rik, basal cell adhesion molecule (Lutheran blood group), B-CAM, Gplu, Lu

BCAM Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 84 kDa and the accession number is Q9R069.

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BCAM Protein, Mouse, Recombinant (hFc)

规格	价格/CNY		货期	数量
50 μg	￥ 3,820		5日内发货

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参考文献

生物活性	Measured by the ability of the immobilized protein to support the adhesion of HOS human osteogenic sarcoma cells. When cells are added to coated plates(5 μg/mL,100μL/well), approximately 30-70% will adhere after 1 hour at 37℃.
产品描述	BCAM Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 84 kDa and the accession number is Q9R069.

种属	Mouse
表达系统	HEK293 Cells
标签	C-hFc
蛋白编号	Q9R069
别名	1200005K12Rik, basal cell adhesion molecule (Lutheran blood group), B-CAM, Gplu, Lu
蛋白构建	The extracellular domain of Mouse BCAM (Q9R069) (Met 1-Ala 541) was fused with the Fc region of Human IgG1 at the C-terminus.
蛋白纯度	> 92 % as determined by SDS-PAGE
分子量	84 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	The Lutheran (Lu) blood group and basal cell adhesion molecule (BCAM) antigens are both carried by 2 glycoprotein isoforms of the immunoglobulin superfamily representing receptors for the laminin alpha(5) chain. It is a transmembrane receptor with five immunoglobulin-like domains in its extracellular region, and is therefore classified as a member of the immunoglobulin (Ig) gene family. In addition to red blood cells, Lu/BCAM proteins are expressed in endothelial cells of vascular capillaries and in epithelial cells of several tissues. BCAM/LU has a wide tissue distribution with a predominant expression in the basal layer of the epithelium and the endothelium of blood vessel walls. As designated as CD239 recently, BCAM and LU share a significant sequence similarity with the CD146 (MUC18) and CD166, and themselves are adhesion molecules that bind laminin with high affinity. Laminins are found in all basement membranes and are involved in cell differentiation, adhesion, migration, and proliferation. BCAM is upregulated following malignant transformation of some cell types in vivo and in vitro, thus being a candidate molecule involved in tumor progression. In addition, BCAM interacts with integrin in sickle red cells, and thus may potentially play a role in vaso-occlusive episodes.

参考文献

1. Kikkawa Y,et al.(2005) Review: Lutheran/B-CAM: a laminin receptor on red blood cells and in various tissues. Connect Tissue Res. 46 (4-5): 193-9. 2. El Nemer W,et al.(2007) Endothelial Lu/BCAM glycoproteins are novel ligands for red blood cell alpha4beta1 integrin: role in adhesion of sickle red blood cells to endothelial cells. Blood. 109 (8): 3544-51. 3. Colin Y,et al.(2008) Red cell and endothelial Lu/BCAM beyond sickle cell disease. Transfus Clin Biol. 15 (6): 402-5. 4. El Nemer W,et al.(2008) Role of Lu/BCAM in abnormal adhesion of sickle red blood cells to vascular endothelium. Transfus Clin Biol. 15 (1-2): 29-33.

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Keywords

BCAM Protein, Mouse, Recombinant (hFc) 1200005K12Rik basal cell adhesion molecule (Lutheran blood group) B-CAM Lutheran blood group Gplu Lu basal cell adhesion molecule recombinant recombinant-proteins proteins protein

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