B7-2 Protein, Human, Recombinant (Avi & His), Biotinylated is expressed in HEK293 mammalian cells with C-Avi-6xHis tag. The predicted molecular weight is 55-80 KDa and the accession number is AAH40261.1.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
20 μg | ¥ 2,260 | 5日内发货 | ||
100 μg | ¥ 6,130 | 5日内发货 |
生物活性 | Loaded Human CTLA-4-Fc on Protein A Biosensor, can bind Human B7-2-His-Avi with an affinity constant of 0.37 uM as determined in BLI assay. (Regularly tested) |
产品描述 | B7-2 Protein, Human, Recombinant (Avi & His), Biotinylated is expressed in HEK293 mammalian cells with C-Avi-6xHis tag. The predicted molecular weight is 55-80 KDa and the accession number is AAH40261.1. |
种属 | Human |
表达系统 | HEK293 Cells |
标签 | C-Avi-6xHis |
蛋白编号 | AAH40261.1 |
别名 | Activation B7-2 Antigen, FUN-1, CTLA-4 Counter-Receptor B7.2, CD28LG2, BU63, T-Lymphocyte Activation Antigen CD86, B70, CD86 |
氨基酸序列 | Ala24-Pro247 |
蛋白构建 | Ala24-Pro247 |
蛋白纯度 | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
分子量 | 55-80 KDa (reducing condition) |
内毒素 | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
缓冲液 | Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM PB, 150 mM NaCl, pH 7.4. |
复溶方法 | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
存储 |
Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
运输方式 |
In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice. |
研究背景 | The protein is the receptor that involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. It may play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. The protein interacts with MARCH8, human herpesvirus 8 MIR2 protein, adenovirus subgroup B fiber proteins and acts as a receptor for these viruses.It is expressed by activated B-lymphocytes and monocytes and promoted by MARCH8 and results in endocytosis and lysosomal degradation.It contains 1 Ig-like C2-type(immunoglobulin-like) domainand 1 Ig-like V-type (immunoglobulin-like) domain. |
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B7-2 Protein, Human, Recombinant (Avi & His), Biotinylated BU-63 FUN 1 Activation B7-2 Antigen FUN-1 BU 63 CTLA-4 Counter-Receptor B7.2 B-70 B 70 CD28LG2 BU63 FUN1 CD 86 CD-86 T-Lymphocyte Activation Antigen CD86 B70 CD86 recombinant recombinant-proteins proteins protein