PI3K/Akt/mTOR信号通路
PI3K/Akt/mTOR signaling

The PI3K/AKT/mTOR pathway is an intracellular signaling pathway important in regulating the cell cycle. Therefore, it is directly related to cellular quiescence, proliferation, cancer, and longevity. PI3K activation phosphorylates and activates AKT, localizing it in the plasma membrane. AKT can have a number of downstream effects such as activating CREB, inhibiting p27,localizing FOXO in the cytoplasm, activating PtdIns-3ps, and activating mTOR which can affect transcription of p70 or 4EBP1. There are many known factors that enhance the PI3K/AKT pathway including EGF, shh, IGF-1, insulin, and CaM. Both leptin and insulin recruit PI3K signalling for metabolic regulation. The pathway is antagonized by various factors including PTEN, GSK3B, and HB9.

PI3K/Akt/mTOR signaling Diagram
X

相关产品

Akt (130) AMPK (68) ATM/ATR (28) DNA-PK (35) GSK-3 (60) MELK (5) mTOR (90) PDK (17) PI3K (209) PTEN (5) S6 Kinase (29) SIK (3) PI4K (3)
陶素的所有产品和服务仅用于科学研究,我们不为任何其他用途提供产品和服务,也不为任何个人提供产品和服务。
微信公众号
Copyright © 2018 Topscience Co. Ltd. All rights reserved. 沪ICP备20019793号-2 沪公网安备 31010602004043号