TN1560
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Dehydroeffusol
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Dehydroeffusol 通过选择性诱导肿瘤抑制性内质网应激和中度细胞凋亡来抑制胃癌细胞生长和致瘤性,具有抗癌、抗焦虑和镇静作用。
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TN1601
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Effusol
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Effusol 是一种从Juncus effuses中分离到的酚类物质,对 DPPH 自由基(IC50:79 μM) 及 ABTS 自由基(IC50:2.73 μM)具有较强的清除活性。它能挽救皮质酮减弱的 CA1 LTP,保护海马功能对抗应激诱导的认知能力下降。
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TN1650
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Friedelin
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Friedelin 是分离自Maytenus ilicifolia(Mart) 的叶子。它是CYP3A4的非竞争性抑制剂,其IC50和Ki分别为10.79 μM 和 6.16 μM,也是CYP2E1的竞争性抑制剂,其IC50和Ki分别为 22.54 μM 和 18.02 μM。
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TN1814
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Juncusol
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Juncusol shows anxiolytic and sedative activities, it shows anxiolytic activity at dosages of 10 mg/kg; it can induce caspase-3-mediated cytotoxicity in HT22 cells. Juncusol has anti-microbial activity, it shows significant activity against MRSA strains.
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TN3809
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Dehydrojuncusol
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Dehydrojuncusol, a new inhibitor of hepatitis C virus RNA replication, it inhibits infection of different HCV genotypes by targeting the NS5A protein and is active against resistant HCV variants frequently found in patients with treatment failure.
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