酪氨酸激酶分子库

Tyrosine Kinase Inhibitor Library
产品编号 L2200
  库化合物信息   Excel SDF

蛋白激酶(PK)是正常细胞信号转导的重要介质,通过对底物蛋白的磷酸化来调节它们的活性、定位和整体功能。蛋白激酶参与几乎所有细胞过程的活动,在细胞增殖、血管生成、迁移、细胞周期等过程中发挥关键作用。在众多蛋白激酶中,酪氨酸蛋白激酶(TK)可能是癌症治疗较有吸引力的靶点,因为TK信号异常通常与肿瘤发生发展密切相关,此外,TK在炎症和类风湿性关节炎等其他疾病中也起着关键作用。

TargetMol 酪氨酸激酶分子库精选747种酪氨酸激酶抑制剂,用于研究酪氨酸激酶相关的疾病和药物,可用于高通量筛选和高内涵筛选。

酪氨酸激酶分子库
规格 价格/RMB
30 μL * 10 mM (in DMSO) 46300.00
100 μL * 10 mM (in DMSO) 99800.00
250 μL * 10 mM (in DMSO) 172557.00
1 mg 172557.00
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产品描述

  • 747种酪氨酸激酶抑制剂的独特集合,可用于高通量筛选和高内涵筛选;
  • 靶点含c-kit、c-Met、EGFR、FGFR、SRC、JAK、SYK、Btk、Bcr-Abl等;
  • 通过临床前研究和临床实验,生物活性和安全性已经得到验证,部分产品已被FDA批准上市;
  • 结构多样,药效显著,可渗透细胞;
  • 详细的说明书,化合物结构、靶点信息、IC50值、活性描述等;
  • NMR、HPLC/LCMS等多种检测技术保证产品结构正确,纯度高,减少假阳性。

化合物库定制

我们的化合物库可以灵活定制! 了解更多

包装和存储

  • 干粉或者DMSO溶液置于带二维码的储存管中,或排列于96孔板/384孔板;
  • 蓝冰运输
获取筛选库化合物信息 (L2200)

化合物库组成

EGFR (100)
VEGFR (91)
Src (58)
FGFR (54)
PDGFR (53)
FLT (48)
JAK (46)
c-Kit (41)
c-Met/HGFR (41)
ALK (38)
Bcr-Abl (38)
Tyrosine Kinases (33)
Raf (26)
BTK (25)
c-RET (22)
HER (22)
TAM Receptor (21)
Trk receptor (21)
MEK (19)
CDK (15)
IGF-1R (14)
Aurora Kinase (13)
PI3K (13)
Syk (12)
FAK (12)
mTOR (11)
PKA (10)
c-Fms (10)
CSF-1R (10)
PKC (9)
TGF-beta/Smad (8)
S6 Kinase (7)
DNA-PK (7)
Discoidin Domain Receptor (DDR) (6)
Tie-2 (6)
Potassium Channel (6)
ROCK (5)
Serine/threonin kinase (5)
p38 MAPK (5)
Akt (5)
ATM/ATR (5)
AChR (5)
Ephrin Receptor (5)
ERK (5)
Chk (4)
MLK (4)
ROS (4)
MAPK (4)
PYK2 (4)
Tyrosinase (4)
TNF (3)
Casein Kinase (3)
DNA/RNA Synthesis (3)
ACK (3)
Apoptosis (3)
5-HT Receptor (3)
Hck (3)
DYRK (3)
IκB/IKK (3)
JNK (3)
Microtubule Associated (2)
Histone Methyltransferase (2)
HSP (2)
GSK-3 (2)
Estrogen/progestogen Receptor (2)
Glucokinase (2)
CaMK (2)
Adrenergic Receptor (2)
Dehydrogenase (2)
SGK (2)
Serine Protease (2)
PPAR (2)
PTEN (2)
PLK (2)
P450 (2)
PDE (1)
NADPH (1)
NAMPT (1)
NF-κB (1)
Pim (1)
Monoamine Transporter (1)
MTH1 (1)
PDK (1)
Phospholipase (1)
PTP1B (1)
Prostaglandin Receptor (1)
Sodium Channel (1)
STAT (1)
VDA (1)
DNA Alkylation (1)
Dopamine Receptor (1)
cell cycle arrest (1)
CRM1 (1)
AhR (1)
Adenosine Receptor (1)
Antibacterial (1)
Antioxidant (1)
Antiviral (1)
Autophagy (1)
GRK (1)
FAAH (1)
Haspin Kinase (1)
HDAC (1)
E1/E2/E3 Enzyme (1)
Epigenetic Reader Domain (1)
Free radical scavengers (1)
GABA Receptor (1)
Glucocorticoid Receptor (1)
HIF (1)
Histamine Receptor (1)
IL Receptor (1)
Integrin (1)
IRAK (1)
LDL (1)
LRRK2 (1)
lysosomal autophagy (1)
MAO (1)

化合物库信息示例

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE
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