PI3K/Akt/mTOR 化合物库

PI3K-AKT-mTOR Compound Library
产品编号 L1300
  库化合物信息   Excel SDF

The PI3K/AKT/mTOR pathway is an intracellular signaling pathway important in regulating the cell cycle. Therefore, it is directly related to cellular quiescence, proliferation, cancer, and longevity. Phosphatidylinositol 3-kinase (PI3K), AKT, a serine/threonine protein kinase also known as protein kinase B (PKB), and mammalian target of rapamycin (mTOR) are 3 major nodes in the pathway. PI3K activation phosphorylates and activates AKT, localizing it in the plasma membrane. AKT can have a number of downstream effects such as activating CREB, inhibiting p27, localizing FOXO in the cytoplasm, activating PtdIns-3ps, and activating mTOR which can affect transcription of p70 or 4EBP1. mTOR is a component of the PI3K/AKT cell survival pathway that monitors the availability of nutrients, mitogenic signals and cellular energy and oxygen levels, a major regulator of the autophagic process, and alterations in components of the mTOR pathway have a major role in tumor progression. Therefore, mTOR is an appealing therapeutic target in many tumors. Encouraging data from preclinical studies have offered new opportunities to fully exploit the therapeutic potential of mTOR targeting in cancer.

The PI3K/Akt/mTOR Compound Library by TargetMol, containing 319 compounds targeting PI3K/Akt/mTOR signaling, can be used for high throughput screening and high content screening for new drugs.

PI3K/Akt/mTOR 化合物库
规格 价格/RMB
100 μL * 10 mM (in DMSO) 71000.00
250 μL * 10 mM (in DMSO) 110000.00
1 mg 110000.00
咨询化合物库

PI3K / AKT / mTOR信号传导通路是调节细胞周期非常重要的一条通路,在细胞生长、存活、增殖、凋亡、血管生成、自吞噬等过程中发挥着极其重要的生物学功能。该通路由PI3激酶(PI3K )、蛋白激酶B(Akt)和哺乳动物类雷帕霉素靶蛋白(mTor)三个作用分子组成, PI3K活化后,通过PIP3 的作用,磷酸化并激活Akt,Akt可以有许多下游效应,如激活CREB,抑制p27,在细胞质中定位FOXO,激活PtdIns-3ps。mTOR已经被确定是PI3K/Akt下游一个重要靶点,是自噬调节中研究最多的靶蛋白之一,是调控肿瘤细胞自噬最经典的通路。因此该通路被广泛地研究并开发新的抗肿瘤制剂,mTOR的抑制剂对于多种肿瘤的治疗已取得了很好的研究结果。

PI3K/Akt/mTOR化合物库是319个与PI3K/Akt/mTOR信号通路相关的小分子化合物的独特集合,可用于高通量、高内涵筛选;

PI3K/Akt/mTOR化合物库是319个与PI3K/Akt/mTOR信号通路相关的小分子化合物的独特集合,可用于高通量、高内涵筛选。

产品描述

  • 319种与PI3K/Akt/mTOR相关的生物活性小分子化合物的特有集合,用于PI3K/Akt/mTOR相关研究以及高通量、高内涵筛选;
  • 是研究细胞及肿瘤细胞生长、增殖、凋亡的有效工具; 
  • 靶点含Akt、AMPK、mTOR、PI3K、ATR/ATM等;
  • 结构多样,药效显著,可渗透细胞;
  • 详细的说明书,化合物结构、靶点信息、IC50值、活性描述等;
  • NMR、HPLC/LCMS等多种检测技术保证产品结构正确,纯度高,减少假阳性。

化合物库定制

我们的化合物库可以灵活定制! 了解更多

包装和存储

  • 干粉或者DMSO溶液置于带二维码的储存管中,或排列于96孔板/384孔板;
  • 蓝冰运输
获取筛选库化合物信息 (L1300)

化合物库组成

PI3K (111)
mTOR (58)
Akt (40)
GSK-3 (35)
AMPK (33)
DNA-PK (27)
S6 Kinase (21)
ATM/ATR (20)
CDK (14)
Autophagy (9)
ERK (8)
PDK (8)
PKA (6)
PKC (5)
STAT (5)
VEGFR (5)
MEK (5)
NF-κB (4)
p38 MAPK (4)
Src (4)
ROCK (3)
FLT (3)
Chk (3)
Apoptosis (3)
AChR (2)
Adrenergic Receptor (2)
BACE (2)
Aurora Kinase (2)
Carbonic Anhydrase (2)
Casein Kinase (2)
EGFR (2)
PDE (2)
Glucokinase (2)
Antioxidant (2)
MMP (2)
Hck (2)
IGF-1R (2)
JNK (2)
S1P Receptor (2)
PI4K (2)
Raf (2)
SIK (2)
TNF (2)
Trk receptor (1)
TRP/TRPV Channel (1)
Tyrosinase (1)
Tyrosine Kinases (1)
Wnt/beta-catenin (1)
TGF-beta/Smad (1)
Sirtuin (1)
Salt-Inducible Kinase (1)
Serine Protease (1)
Serine/threonin kinase (1)
SGK (1)
Pim (1)
PLK (1)
Potassium Channel (1)
PTEN (1)
Lipase (1)
LRRK2 (1)
lysosomal autophagy (1)
MAPK (1)
IL Receptor (1)
Immunology & Inflammation related (1)
Integrin (1)
JAK (1)
HDAC (1)
HER (1)
HIF (1)
HIF/HIF Prolyl-Hydroxylase (1)
HIV Protease (1)
HSP (1)
HSV (1)
NADPH (1)
GluR (1)
MELK (1)
PDGFR (1)
P450 (1)
p53 (1)
PAK (1)
Endogenous Metabolite (1)
Epigenetic Reader Domain (1)
GABA Receptor (1)
Estrogen/progestogen Receptor (1)
FAK (1)
Fatty Acid Synthase (1)
FGFR (1)
cholecystokinin (1)
c-Kit (1)
c-RET (1)
Cysteine Protease (1)
Dehydrogenase (1)
c-Fms (1)
Dopamine Receptor (1)
BCL (1)
Bcr-Abl (1)
Calcium Channel (1)
CaMK (1)
ALK (1)
Apoptosis inducer (1)
Antifection (1)

化合物库信息示例

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE
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