共价片段库

Covalent Fragment Library
产品编号 EN4700
  库化合物信息   Excel SDF

Covalent chemical probes have become a hot topic in drug discovery within the last few years. The impressive number of successful applications in protein drugability assessment and in the investigation of enzymes functions brought aspiration to the discovery of new covalent modifiers. Covalent Fragment Library contains 6120 compounds.

共价片段库
规格 价格/RMB
100 μL * 10 mM (in DMSO) 待询
250 μL * 10 mM (in DMSO) 待询
1 mg 待询
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Further progress in this area is limited by the availability of new covalent fragments with balanced molecular properties. We have recently elaborated parallel chemistry approaches to the synthesis of new libraries encompassing covalent fragments of various classes. Only within last year, Enamine has synthesized over 18,000 new covalent binders by parallel chemistry. The acquired knowledge on stability and selectivity was applied to the design of our new Covalent Fragment Library.

Key features

  • Careful choice of warheads: only experimentally confirmed reactivity, reported in the literature.
  • The latest achievements in covalent anchor chemistry, new modification of well-known covalent moieties.
  • Advanced covalent warheads: reactivity-controlled covalent binders, N/O-sulfonyl fluorides, azididines, expoxides, 2-chloropropionamides.
  • Fragments plated by classes and can be acquired separately.
  • Novel compounds featuring renowned Enamine Building Blocks.
  • Careful choice of highly tractable and attractive covalent functionalities makes this library the most reliable source of covalent fragments. All compounds passed QC check (90%+ purity) before formatting to ensure quality of our library.

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包装和存储

  • 干粉或者DMSO溶液置于带二维码的储存管中,或排列于96孔板/384孔板;
  • 蓝冰运输
获取筛选库化合物信息 (EN4700)
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