首页化合物库上市药物库
上市药物库
APPROVED DRUG LIBRARY

Catalog No.L1000

传统的药物开发涉及从头确认和验证新分子实体,这是一个耗时且成本高昂的过程,随着对药物安全性及有效性的要求不断提高,开发新药的成本还将持续上涨。由于时间和成本大幅降低,近年来药物功能重定位受到越来越多关注,高内涵筛选、新的生物标志物发现和生物信息学的快速发展为基于靶点或细胞的药物重定位创造了机会。

上市药物都具有已知的和良好表征的生物活性、安全性和生物利用度,这些特征可以显著加速药物开发和优化,从上市药物中筛出的苗头化合物将为后续的药物优化计划提供最有利的线索。

此外,由于活性明确,靶点已知,很多科学家会从上市药物库中选择可以用于细胞诱导分化的小分子,通过单一或几个小分子的联合作用,选择出将各种体细胞诱导成为诱导多能干细胞、神经前体细胞、心肌细胞等,甚至还有使用小分子组合在体内完成诱导分化的成功尝试。

Pack Size Price
100 μL * 10 mM (in DMSO) RMB 105390.00
250 μL * 10 mM (in DMSO) RMB 189699.00
1 mg RMB 189699.00
产品特性
  • 2342个上市药物化合物集合,可用于高通量筛选和高内涵筛选;
  • 所有化合物得到FDA、EMA、CFDA等权威部门审批或收录在USP、EP,BP、JP、CP等药典文献中;
  • 老药新用、新的药物靶点筛选的有效工具;
  • 涵盖多个研究领域:肿瘤、心血管药物、抗炎/免疫、神经系统药物、呼吸系统药物等;
  • 详细的说明书,化合物结构、靶点信息、IC50值、活性描述等;
  • 结构多样,药效显著,可渗透细胞;
  • NMR、HPLC/LCMS等多种检测技术保证产品结构正确,纯度高,减少假阳性。
包装与存储
  • 形式:可提供1 mg、5 mg的干粉以及DMSO 10 mM浓度的各种规格溶液;
  • 包装:化合物溶液置于带旋盖和二维码的储存管中,后排列于96孔板;
  • 保存:干粉可保存两年;溶于DMSO,-20 °C可保存一年,-80 °C 可保存两年,避免反复冻融;
  • 运输:蓝冰运输。
化合物库组成成分
AChR (124)
Adrenergic Receptor (116)
5-HT Receptor (115)
Antibiotic (99)
COX (94)
Dopamine Receptor (76)
Antibacterial (72)
DNA/RNA Synthesis (65)
Histamine Receptor (64)
Sodium Channel (56)
Potassium Channel (50)
Estrogen/progestogen Receptor (46)
Glucocorticoid Receptor (41)
Calcium Channel (41)
Topoisomerase (38)
Autophagy (35)
GR (35)
Vitamin (34)
PDE (32)
ribosome (30)
GABA Receptor (26)
EGFR (25)
Dehydrogenase (25)
PPAR (25)
RAAS (25)
VEGFR (24)
Norepinephrine (23)
P450 (22)
Antifection (22)
Microtubule Associated (22)
MAO (21)
HIV Protease (20)
Antifungal (20)
c-Kit (19)
PDGFR (18)
Carbonic Anhydrase (17)
ATPase (17)
NF-κB (16)
MRP (15)
Opioid Receptor (15)
Reverse Transcriptase (15)
HCV Protease (15)
HDAC (15)
Bcr-Abl (14)
DNA Alkylation (14)
GluR (13)
TNF (13)
Src (12)
Thrombin (12)
ROS (12)
FLT (12)
Amino Acids and Derivatives (12)
Androgen Receptor (12)
DHFR (11)
Endogenous Metabolite (11)
IL Receptor (11)
NMDAR (11)
Retinoid Receptor (10)
Tyrosine Kinases (10)
Thyroid hormone receptor(THR) (9)
Proton pump (9)
PKC (9)
Prostaglandin Receptor (9)
NADPH (9)
FGFR (9)
DNA gyrase (9)
CAT (8)
ABC (8)
DPP-4 (8)
HMG-CoA Reductase (8)
Lipoxygenase (8)
Raf (8)
MMP (7)
Parasite (7)
P2 Receptor (7)
Transferase (7)
TRP/TRPV Channel (7)
JAK (7)
Factor Xa (7)
HBV (7)
CaMK (7)
CDK (6)
AMPK (6)
Annexin A (6)
Tyrosinase (6)
STAT (6)
Proteasome (6)
Reductase (5)
SGLT (5)
Serine Protease (5)
Phospholipase (5)
MPO (5)
Antiviral (5)
Aromatase (5)
Adenosine Receptor (5)
CFTR (5)
DNA Methyltransferase (5)
Chloride channel (5)
Integrin (5)
Lipid (5)
HER (5)
HSV (5)
Influenza Virus (4)
HIF (4)
Hedgehog/Smoothened (4)
IκB/IKK (4)
GPR (4)
GNRH Receptor (4)
Fatty Acid Synthase (4)
Endothelin Receptor (4)
CXCR (4)
ALK (4)
mTOR (4)
PARP (4)
Neurokinin receptor (4)
NOS (4)
PI3K (4)
PKA (4)
Sirtuin (3)
p38 MAPK (3)
MT Receptor (3)
Monoamine Transporter (3)
Na-K-Cl cotransporter (3)
NOD (3)
TLR (3)
TAM Receptor (3)
UGT (3)
Vasopressin Receptor (3)
AhR (3)
BCL (3)
Arginase (3)
Antioxidant (3)
Cysteine Protease (3)
Decarboxylase (3)
c-Met/HGFR (3)
c-RET (3)
Cell wall (3)
Free radical scavengers (3)
Glucokinase (3)
GluCls (3)
GSK-3 (3)
GST (3)
LTR (3)
MEK (3)
Melatonin Receptor (2)
MAPK (2)
Mitophagy (2)
Histone Methyltransferase (2)
LDL (2)
IGF-1R (2)
Gap Junction Protein (2)
Glutathione reductase (2)
GlyT (2)
FXR (2)
Ferroptosis (2)
Ephrin Receptor (2)
Epigenetic Reader Domain (2)
Chk (2)
CCR (2)
BTK (2)
Cannabinoid Receptor (2)
DNA (2)
Akt (2)
ACAT (2)
Syk (2)
TGF-beta/Smad (2)
Monocarboxylate transporter (2)
Nucleoside Antimetabolite/Analog (2)
Serine/threonin kinase (2)
Phosphatase (2)
Rho (2)
ROCK (2)
Platelet aggregation (2)
PLK (2)
Protease-activated Receptor (2)
RAR/RXR (1)
Ras (1)
PDK (1)
PED (1)
P-gp (1)
ROR (1)
Serotonin Transporter (1)
S1P Receptor (1)
S6 Kinase (1)
Sigma receptor (1)
OAT (1)
NPC1L1 (1)
Nrf2 (1)
OX Receptor (1)
p53 (1)
PAFR (1)
Monoamine Oxidase (1)
N-Acetylglucosaminyltransferase (1)
NOD-like Receptor (NLR) (1)
NKCC (1)
NADPH-oxidase (1)
Wnt/beta-catenin (1)
Somatostatin (1)
Telomerase (1)
VDA (1)
AChE (1)
advanced glycation end products (1)
ACK (1)
Acyltransferase (1)
Anion Exchanger (1)
Aminopeptidase (1)
BACE (1)
ATM/ATR (1)
ATP Citrate Lyase (1)
Aurora Kinase (1)
DNA Alkylator/Crosslinker (1)
CRM1 (1)
CSF-1R (1)
cholecystokinin (1)
Caspase (1)
CaSR (1)
cAMP (1)
Beta Amyloid (1)
Beta-Secretase (1)
CETP (1)
c-Fms (1)
DUB (1)
Electron transport (1)
FAK (1)
GPCR19 (1)
Glucagon Receptor (1)
Hck (1)
GRK (1)
iGluR (1)
Integrase (1)
Hydrogenase (1)
Hydroxylase (1)
IAP (1)
HIF/HIF Prolyl-Hydroxylase (1)
HSP (1)
Histone Demethylase (1)
lysosomal autophagy (1)
JNK (1)
Mitochondrial Metabolism (1)
陶素化合物库特点:
  • 详细的化学结构
  • 二维码储存管
  • 蓝冰干冰运输
  • NMR和HPLC保证产品纯度

默认产品规格为:
  • 1mg/well (powder)
  • 100μL/well (10mM solution)
  • 250μL/well (10mM solution)

* 产品高度可定制化,用户可以选择自己的化合物组库。
技术支持
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联系陶素
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