抗癌临床化合物库

Anti-cancer Clinical Compound Library
产品编号 L2120
  库化合物信息   Excel SDF

尽管在过去的几十年中癌症的研究和治疗取得了巨大的成功,但癌症仍然是人类面临的巨大挑战,给患者身心健康带来巨大的痛苦。癌细胞具有许多显著不同的生物学特征,表现出无限的增殖潜能,维持自身生长信号的持续稳定,逃避应激信号(例如治疗药物)诱导的细胞凋亡,刺激血管生长,为肿瘤提供营养,同时逃避免疫系统防御和诱导局部慢性炎症,发挥其侵袭和转移能力,表现出异常的代谢活动,并通过突变和表观遗传机制显著改变全基因组的稳定性。

抗癌活性的药物是临床研究的热点之一,根据文献报道和有关公开资料,我们收集了1776个具有抗癌活性或潜在抗癌活性的处于临床试验阶段的化合物,组成抗癌临床化合物库,可用于癌症相关研究及高通量高内涵筛选。

抗癌临床化合物库
规格 价格/RMB
100 μL * 10 mM (in DMSO) 173154.00
250 μL * 10 mM (in DMSO) 284160.00
1 mg 284160.00
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产品描述

  • 1776个具有抗癌活性小分子的独特集合,可用于高通量高内涵筛选;
  • 生物活性已经临床前实验证实,所有化合物均已进入临床实验阶段的抗癌化合物;
  • 包括肺癌、乳腺癌、白血病、淋巴瘤等15种癌症,是癌症相关研究的有效筛选工具;
  • 作用靶点涉及PI3K,HDAC, mTOR, CDK, JAK 等癌症相关靶点;
  • 结构多样,药效显著,可渗透细胞;
  • 详细的说明书,化合物结构、靶点信息、IC50值、活性描述等;
  • NMR、HPLC/LCMS等多种检测技术保证产品结构正确,纯度高,减少假阳性。

化合物库定制

我们的化合物库可以灵活定制! 了解更多

包装和存储

  • 干粉或者DMSO溶液置于带二维码的储存管中,或排列于96孔板/384孔板;
  • 蓝冰运输
获取筛选库化合物信息 (L2120)

化合物库组成

DNA/RNA Synthesis (59)
COX (58)
AChR (55)
VEGFR (55)
PI3K (48)
EGFR (38)
CDK (35)
JAK (35)
PDGFR (34)
Dehydrogenase (34)
HDAC (34)
FLT (33)
Estrogen/progestogen Receptor (33)
Topoisomerase (33)
Potassium Channel (33)
FGFR (31)
c-Kit (31)
Adrenergic Receptor (30)
Glucocorticoid Receptor (29)
mTOR (29)
c-Met/HGFR (28)
Microtubule Associated (27)
PPAR (27)
Src (27)
Bcr-Abl (26)
PDE (25)
Sodium Channel (24)
RAAS (23)
Autophagy (22)
GR (22)
Antibacterial (21)
Androgen Receptor (21)
Tyrosine Kinases (21)
P450 (20)
GABA Receptor (20)
DNA Alkylation (18)
Raf (18)
NF-κB (17)
Akt (17)
Antibiotic (16)
Antifection (16)
Carbonic Anhydrase (16)
MEK (16)
ALK (15)
Endogenous Metabolite (15)
Epigenetic Reader Domain (15)
HSP (14)
IL Receptor (14)
BTK (14)
TAM Receptor (14)
PARP (13)
c-RET (13)
Calcium Channel (12)
ATPase (12)
Aurora Kinase (12)
HIF (12)
HER (12)
HIV Protease (12)
DNA-PK (12)
TNF (12)
Retinoid Receptor (12)
Reverse Transcriptase (12)
p38 MAPK (11)
MRP (11)
GPR (11)
GSK-3 (10)
Apoptosis (10)
Adenosine Receptor (10)
CXCR (10)
Integrin (10)
MAO (10)
STAT (10)
Trk receptor (10)
Vitamin (9)
Syk (9)
Thrombin (9)
ROS (9)
PKC (9)
PLK (9)
Gamma-secretase (9)
ERK (8)
Hedgehog/Smoothened (8)
CSF-1R (8)
Chk (8)
Proteasome (8)
S6 Kinase (8)
Transferase (8)
TRP/TRPV Channel (7)
Wnt/beta-catenin (7)
NADPH (7)
P-gp (7)
BCL (7)
CCR (7)
Amino Acids and Derivatives (7)
IDO (7)
DHFR (7)
FAK (6)
HSV (6)
HMG-CoA Reductase (6)
HCV Protease (6)
AMPK (6)
ATM/ATR (6)
Caspase (6)
Antiviral (6)
Beta Amyloid (6)
CFTR (6)
NOS (6)
JNK (6)
S1P Receptor (6)
Prostaglandin Receptor (6)
PKA (5)
Serine Protease (5)
Sirtuin (5)
TLR (5)
Lipoxygenase (5)
IκB/IKK (5)
Mdm2 (5)
NMDAR (5)
Nucleoside Antimetabolite/Analog (5)
Phospholipase (5)
Parasite (5)
p53 (5)
Casein Kinase (5)
Antifungal (5)
AhR (5)
HBV (5)
Hydroxylase (5)
IGF-1R (5)
Glucokinase (5)
DNA gyrase (5)
DNA Methyltransferase (5)
GluR (4)
Fatty Acid Synthase (4)
IAP (4)
HIF/HIF Prolyl-Hydroxylase (4)
Histamine Receptor (4)
Histone Demethylase (4)
Antioxidant (4)
CAT (4)
Cysteine Protease (4)
c-Fms (4)
Pim (4)
MPO (4)
Opioid Receptor (4)
Liver X Receptor (4)
TGF-beta/Smad (4)
ROCK (4)
ribosome (4)
Proton pump (4)
Reductase (3)
Ras (3)
ROR (3)
SGLT (3)
Telomerase (3)
UGT (3)
LTR (3)
LDL (3)
Nrf2 (3)
Na-K-Cl cotransporter (3)
Phosphatase (3)
PAK (3)
CETP (3)
CaMK (3)
ATP Citrate Lyase (3)
Arginase (3)
Aromatase (3)
BACE (3)
ABC (3)
Annexin A (3)
Aminopeptidase (3)
Histone Methyltransferase (3)
GNRH Receptor (3)
Free radical scavengers (3)
Factor Xa (3)
DprE1 (3)
DUB (2)
E1/E2/E3 Enzyme (2)
Dopamine Receptor (2)
DPP-4 (2)
Ferroptosis (2)
DNA (2)
Ephrin Receptor (2)
Gap Junction Protein (2)
GlyT (2)
GPCR19 (2)
ACAT (2)
Acyltransferase (2)
Antifolate (2)
Cannabinoid Receptor (2)
CaSR (2)
cholecystokinin (2)
c-Myc (2)
Decarboxylase (2)
CRM1 (2)
NAMPT (2)
P2 Receptor (2)
MAPK (2)
Kinesin (2)
KSP (2)
Influenza Virus (2)
Mitochondrial Metabolism (2)
Vasopressin Receptor (2)
VDA (2)
Tyrosinase (2)
Thyroid hormone receptor(THR) (2)
Tie-2 (2)
Rho (2)
PYK2 (2)
Protease-activated Receptor (2)
Porcupine (1)
PKM (1)
RAR/RXR (1)
Reactive Oxygen Species (1)
RIP kinase (1)
Smo (1)
Somatostatin (1)
Serotonin Transporter (1)
SGK (1)
Thioredoxin (1)
transporter (1)
Stemness kinase (1)
STING (1)
Survivin (1)
Wee1 (1)
Xanthine Oxidase (1)
Mitophagy (1)
MLK (1)
MMP (1)
MNK (1)
Monoamine Transporter (1)
Monocarboxylate transporter (1)
Melatonin Receptor (1)
MELK (1)
NADPH-oxidase (1)
MT Receptor (1)
MTH1 (1)
Integrase (1)
Isocitrate Dehydrogenase (IDH) (1)
LHRH (1)
Lipid (1)
lysosomal autophagy (1)
OXPHOS (1)
OAT (1)
Neurokinin receptor (1)
NKCC (1)
NOD-like Receptor (NLR) (1)
Norepinephrine (1)
NPC1L1 (1)
p97 (1)
PAI-1 (1)
PDK (1)
Dehydrogenase inhibitor (1)
CPT (1)
Cell wall (1)
Beta-Secretase (1)
Apoptosis inducer (1)
ASK (1)
5-HT Receptor (1)
ACK (1)
Hck (1)
FXR (1)
GST (1)
Guanylate cyclase (1)
Hexokinase (1)
Hydrogenase (1)
Indoleamine 2,3-Dioxygenase (IDO) (1)
GHSR (1)
Glutathione Peroxidase (1)
Discoidin Domain Receptor (DDR) (1)
DNA Alkylator/Crosslinker (1)
Endothelin Receptor (1)
Electron transport (1)

化合物库信息示例

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE
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