Powder: -20°C for 3 years | In solvent: -80°C for 1 year
VB124 是一种具有口服活性的、有效且选择性的MCT4抑制剂。VB124 可特异性抑制 MDA-MB-231 细胞中乳酸的涌入和流出,IC50分别为 8.6 nM 和 19 nM。VB124 对 MCT4 的选择性高于 MCT1。VB124可用于心脏肥大、心力衰竭和代谢的研究。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,220 | 现货 | ||
5 mg | ¥ 2,970 | 现货 | ||
10 mg | ¥ 4,960 | 现货 | ||
25 mg | ¥ 7,580 | 现货 | ||
50 mg | ¥ 9,870 | 现货 | ||
100 mg | ¥ 13,800 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 3,380 | 现货 |
产品描述 | VB124 is an orally active, potent, and selective MCT4 inhibitor, demonstrating specificity in hindering lactate efflux, with IC50 values of 8.6 nM and 19 nM for lactate import and export, respectively, in MDA-MB-231 cells. Its high selectivity for MCT4 over MCT1 positions VB124 as a promising agent for researching cardiac hypertrophy, heart failure, and metabolic disorders [1]. |
体外活性 | VB124 (10 μM) inhibits the cell proliferation of MDA-MB-231 cells, and the cell proliferation rate is less than 50% [1]. VB124 is more selective to MCT4 than MCT1, exhibiting very little MCT1 inhibitory activity (lactate export IC 50 =24 μM) in MCT1-expressing BT20 cells [1]. |
体内活性 | VB124 (30 mg/kg; p.o.; daily for 28 days) reduces isoproterenol-induced cardiac hypertrophy in mice [1]. VB124 (30 mg/kg; twice per day for 180 days) has no effect on the body, heart, liver, or lung weight of mice, suggesting no overt toxicities [1]. Animal Model: 12 weeks old C57BL/6 mice [1] Dosage: 30 mg/kg Administration: Oral gavage; daily for 28 days (dissolved in 0.5% methylcellulose and 0.1% Tween-20) Result: Prevented cardiac hypertrophy in mice. |
分子量 | 426.89 |
分子式 | C23H23ClN2O4 |
CAS No. | 2230186-18-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90 mg/mL (210.8 mM), Sonification is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.3425 mL | 11.7126 mL | 23.4252 mL | 58.5631 mL |
5 mM | 0.4685 mL | 2.3425 mL | 4.685 mL | 11.7126 mL | |
10 mM | 0.2343 mL | 1.1713 mL | 2.3425 mL | 5.8563 mL | |
20 mM | 0.1171 mL | 0.5856 mL | 1.1713 mL | 2.9282 mL | |
50 mM | 0.0469 mL | 0.2343 mL | 0.4685 mL | 1.1713 mL | |
100 mM | 0.0234 mL | 0.1171 mL | 0.2343 mL | 0.5856 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
VB124 2230186-18-0 Membrane transporter/Ion channel Monocarboxylate transporter VB-124 VB 124 Inhibitor inhibitor inhibit