Powder: -20°C for 3 years | In solvent: -80°C for 1 year
UBCS039 是一种合成的 SIRT6特异性激活剂,可在人癌细胞中诱导自噬,其 EC50值为38 μM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 568 | 现货 | ||
2 mg | ¥ 828 | 现货 | ||
5 mg | ¥ 1,350 | 现货 | ||
10 mg | ¥ 2,110 | 现货 | ||
25 mg | ¥ 3,570 | 现货 | ||
50 mg | ¥ 5,160 | 现货 | ||
100 mg | ¥ 7,280 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,260 | 现货 |
产品描述 | UBCS039 is the first synthetic Sirt6 activator(EC50 : 38 μM) |
靶点活性 | SIRT6:38 μM |
体外活性 | UBCS039 induced a time-dependent activation of autophagy in several human tumor cell lines, as evaluated by increased content of the lipidated form of LC3B by western blot and of autophagosomal puncta by microscopy analysis of GFP-LC3.?UBCS039-mediated activation of autophagy was strictly dependent on SIRT6 deacetylating activity since the catalytic mutant H133Y failed to activate autophagy.?At the molecular level, SIRT6-mediated autophagy was triggered by an increase of ROS levels, which, in turn, resulted in the activation of the AMPK-ULK1-mTOR signaling pathway.?Interestingly, antioxidants were able to completely counteract UBCS039-induced autophagy, suggesting that ROS burst had a key role in upstream events leading to autophagy commitment. |
分子量 | 247.29 |
分子式 | C16H13N3 |
CAS No. | 358721-70-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (505.48 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 4.0438 mL | 20.2192 mL | 40.4384 mL | 101.0959 mL |
5 mM | 0.8088 mL | 4.0438 mL | 8.0877 mL | 20.2192 mL | |
10 mM | 0.4044 mL | 2.0219 mL | 4.0438 mL | 10.1096 mL | |
20 mM | 0.2022 mL | 1.011 mL | 2.0219 mL | 5.0548 mL | |
50 mM | 0.0809 mL | 0.4044 mL | 0.8088 mL | 2.0219 mL | |
100 mM | 0.0404 mL | 0.2022 mL | 0.4044 mL | 1.011 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
UBCS039 358721-70-7 Autophagy Chromatin/Epigenetic DNA Damage/DNA Repair Sirtuin UBCS 039 UBCS-039 inhibit Inhibitor inhibitor