Powder: -20°C for 3 years | In solvent: -80°C for 1 year
UAMC00039 dihydrochloride 是可逆、竞争性的 dipeptidyl peptidase II 高效抑制剂,IC50=为0.48 nM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 455 | 现货 | ||
2 mg | ¥ 663 | 现货 | ||
5 mg | ¥ 995 | 现货 | ||
10 mg | ¥ 1,490 | 现货 | ||
25 mg | ¥ 3,290 | 现货 | ||
50 mg | ¥ 4,780 | 现货 | ||
100 mg | ¥ 6,850 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 838 | 现货 |
产品描述 | UAMC00039 dihydrochloride is a potent, reversible and competitive dipeptidyl peptidase II inhibitor with an IC50 of 0.48 nM. |
靶点活性 | DPP2:0.48 nM. |
激酶实验 | Stability of UAMC00039 in RPMI medium or assay buffer (50 mM cacodylate buffer pH5.5) is monitored at 37 °C. The inhibitors' capacity (IC50) to inhibit DPPII is measured at different time points (up to 48 h). U937 cells are incubated with various concentrations of UAMC00039 for 15 min at 37 °C in RPMI. Cells are then ished with PBS, lysed and assayed for DPPII activity. Concentration–response and time–response curves are generated from incubations of PBMC with UAMC00039 (0.01 nM–1 μM) in RPMI at 37 °C for 1, 5, 15, 30 and 60 min. Ished cells are lysed overnight at 4 °C using 100 mM HEPES buffer pH 7.4, 10 mM EDTA, 70 μg/mL aprotinin and 1% octylglucoside. |
动物实验 | Rat: UAMC00039 is administered orally at 2 mg/kg (~5 μMol/kg in a vehicle of 2% tween 80, 10 mL/kg) on a blind basis in all in vivo assays. For each assay, a reference compound and vehicle control is analyzed concurrently. For the in vivo studies 3 to 5 animals per condition are tested. |
别名 | UAMC 00039 dihydrochloride |
分子量 | 382.76 |
分子式 | C16H26Cl3N3O |
CAS No. | 697797-51-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (143.69 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.6126 mL | 13.063 mL | 26.126 mL | 65.3151 mL |
5 mM | 0.5225 mL | 2.6126 mL | 5.2252 mL | 13.063 mL | |
10 mM | 0.2613 mL | 1.3063 mL | 2.6126 mL | 6.5315 mL | |
20 mM | 0.1306 mL | 0.6532 mL | 1.3063 mL | 3.2658 mL | |
50 mM | 0.0523 mL | 0.2613 mL | 0.5225 mL | 1.3063 mL | |
100 mM | 0.0261 mL | 0.1306 mL | 0.2613 mL | 0.6532 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
UAMC00039 dihydrochloride 697797-51-6 Proteases/Proteasome Ubiquitination Proteasome UAMC00039 Dihydrochloride Inhibitor UAMC-00039 dihydrochloride UAMC 00039 UAMC-00039 Dihydrochloride UAMC00039 UAMC 00039 Dihydrochloride DPP UAMC-00039 Dipeptidyl Peptidase inhibit UAMC 00039 dihydrochloride inhibitor