Powder: -20°C for 3 years | In solvent: -80°C for 1 year
trans-C75 ((±)-C75) 是一种 C75 的对映异构体。其中 C75 是一种脂肪酸合成酶 (FASN) 的抑制剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 378 | 现货 | ||
2 mg | ¥ 676 | 现货 | ||
5 mg | ¥ 998 | 现货 | ||
10 mg | ¥ 1,490 | 现货 | ||
25 mg | ¥ 3,590 | 现货 | ||
50 mg | ¥ 5,180 | 现货 | ||
100 mg | ¥ 7,330 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 863 | 现货 |
产品描述 | trans-C75 ((±)-C75) is an enantiomer of C75. C75 is an inhibitor of fatty-acid synthase (FASN). |
靶点活性 | PC3 cell:35 μM (IC50) |
体外活性 | Treatment with C75 alone decreased clonogenic survival, an effect that was abrogated by the antioxidant.?C75 treatment also delayed spheroid growth in a concentration-dependent manner.?The radiosensitizing effect of C75 was indicated by combination index values between 0.65 and 0.71 and the reduced surviving fraction of clonogens, in response to 2 Gy X irradiation, from 0.51 to 0.30 and 0.11 in the presence of 25 and 35 μM C75, respectively.?This increased sensitivity to radiation was reduced by the presence of the antioxidant.?The C75 treatment also enhanced the spheroid growth delay induced by X irradiation in a supra-additive manner.?The level of radiation-induced apoptosis in prostate cancer cells was increased further by C75, which induced cell cycle arrest in the G2/M phase, but only at a concentration greater than that required for radiosensitization. |
别名 | (±)-C75, 反-4-羧基-5-辛基-3-甲基-丁内酯 |
分子量 | 254.32 |
分子式 | C14H22O4 |
CAS No. | 191282-48-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 83.3 mg/mL (327.54 mM), sonification/heating is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.9321 mL | 19.6603 mL | 39.3205 mL | 98.3014 mL |
5 mM | 0.7864 mL | 3.9321 mL | 7.8641 mL | 19.6603 mL | |
10 mM | 0.3932 mL | 1.966 mL | 3.9321 mL | 9.8301 mL | |
20 mM | 0.1966 mL | 0.983 mL | 1.966 mL | 4.9151 mL | |
50 mM | 0.0786 mL | 0.3932 mL | 0.7864 mL | 1.966 mL | |
100 mM | 0.0393 mL | 0.1966 mL | 0.3932 mL | 0.983 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
trans-C75 191282-48-1 Metabolism Others Fatty Acid Synthase C 75 (±)-C75 trans-C-75 Fatty Acid Synthase (FASN) Inhibitor 反-4-羧基-5-辛基-3-甲基-丁内酯 C-75 inhibit trans C75 transC75 C75 inhibitor