Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tofisopam (Grandaxin) 是2,3-苯二氮卓类化合物,具有抗焦虑活性,可口服。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 259 | 现货 | ||
5 mg | ¥ 587 | 现货 | ||
10 mg | ¥ 837 | 现货 | ||
25 mg | ¥ 1,490 | 现货 | ||
50 mg | ¥ 2,150 | 现货 | ||
100 mg | ¥ 3,160 | 现货 | ||
200 mg | ¥ 4,570 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 548 | 现货 |
产品描述 | Tofisopam (Grandaxin) is a 2,3-benzodiazepine compound with anxiolytic activity that can be taken orally. |
体内活性 | Tofisopam (30 and 100 mg/kg, po) significantly inhibited the gastric ulceration induced by water-immersion stress in normal rats in a dose-dependent manner. Immobilization-stress loading increased the incidence and average index of gastric ulceration in OB rats, compared with nonstressed rats. Tofisopam (100 mg/kg, po) significantly inhibited the gastric ulceration induced by stress loading in OB rats. Water-immersion stress loading induced a significant increase in intestinal propulsion in rats. This increase was reversed to control levels by tofisopam (100 mg/kg, po). Tofisopam (1.0 mg/kg, iv, or 0.1 mg/kg by intracerebrospinal injection) inhibited the constriction of ear microvessels, the decrease in earlobe temperature, and mydriasis induced by electrical stimulation of the medial hypothalamic area in rabbits[2]. |
别名 | Emandaxin, 托非索洋, Grandaxin |
分子量 | 382.45 |
分子式 | C22H26N2O4 |
CAS No. | 22345-47-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (130.74 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.6147 mL | 13.0736 mL | 26.1472 mL | 65.368 mL |
5 mM | 0.5229 mL | 2.6147 mL | 5.2294 mL | 13.0736 mL | |
10 mM | 0.2615 mL | 1.3074 mL | 2.6147 mL | 6.5368 mL | |
20 mM | 0.1307 mL | 0.6537 mL | 1.3074 mL | 3.2684 mL | |
50 mM | 0.0523 mL | 0.2615 mL | 0.5229 mL | 1.3074 mL | |
100 mM | 0.0261 mL | 0.1307 mL | 0.2615 mL | 0.6537 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Tofisopam 22345-47-7 Others Emandaxin anxiolytic agent 托非索洋 inhibit orally active Inhibitor Grandaxin inhibitor