Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Stylopine hydrochloride 是一种生物碱类化合物,从紫堇属之植物块茎中分离得到,具有抗炎症和抗寄生虫作用。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 378 | 现货 | ||
5 mg | ¥ 828 | 现货 | ||
10 mg | ¥ 1,330 | 现货 | ||
25 mg | ¥ 2,230 | 现货 | ||
50 mg | ¥ 3,330 | 现货 | ||
100 mg | ¥ 4,770 | 现货 |
产品描述 | Stylopine is a protoberberine-type alkaloid that has potential biological activities, including anti-inflammatory activity. |
体外活性 | Stylopine is a major component of the leaf of Chelidonium majus L. (Papaveraceae), which has been used for the removal of warts, papillomas and condylomas, as well as the treatment of liver disease, in oriental countries.?Stylopine per se had no cytotoxic effect in unstimulated RAW 264.7 cells, but concentration-dependently reduced nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), and the IL-6 production and cyclooxygenase-2 (COX-2) activity caused by the LPS stimulation.?The levels of inducible nitric oxide synthase (iNOS) and COX-2 protein expressions were markedly suppressed by stylopine in a concentration dependent manner.?Suggest that stylopine suppress the NO and PGE2 production in macrophages by inhibiting the iNOS and COX-2 expressions.?These biological activities of stylopine may contribute to the anti-inflammatory activity of Chelidonium majus. |
分子量 | 359.8 |
分子式 | C19H18ClNO4 |
CAS No. | 96087-21-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 5 mg/mL (13.89 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.7793 mL | 13.8966 mL | 27.7932 mL | 69.483 mL |
5 mM | 0.5559 mL | 2.7793 mL | 5.5586 mL | 13.8966 mL | |
10 mM | 0.2779 mL | 1.3897 mL | 2.7793 mL | 6.9483 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Stylopine hydrochloride 96087-21-7 Immunology/Inflammation Neuroscience NOS COX alkaloid (±)-Stylopine Corydalis Inhibitor Tetrahydrocoptisine anti-parasitic inhibit Stylopine Hydrochloride inhibitor