Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Slingshot inhibitor D3 (JHN76359) 是具有选择性、竞争性、可逆性的Slingshot 抑制剂。它对Slingshot 1和Slingshot 2具有相似的抑制活性。它对Slingshot 1 的IC50为 3 μM;对Slingshot 2 的Ki 为 3.9 μM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 498 | 现货 | ||
5 mg | ¥ 1,150 | 现货 | ||
10 mg | ¥ 1,980 | 现货 | ||
25 mg | ¥ 3,370 | 现货 | ||
50 mg | ¥ 4,890 | 现货 | ||
100 mg | ¥ 6,860 | 现货 | ||
500 mg | ¥ 13,800 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,230 | 现货 |
产品描述 | Slingshot inhibitor D3 (JHN76359) is a potent inhibitor of the Protein Phosphatase Slingshot. |
靶点活性 | SSH:3 Μm(Slingshot 1 ), SSH:3.9 μM (Ki; Slingshot 2) |
体外活性 | Slingshot 1 had?IC50?value of 3 μM and Slingshot 2 had?Ki value of 3.9 μM.?Slingshot inhibitor D3 has similar inhibitory activitieswith Slingshot 1 and Slingshot 2. |
体内活性 | Slingshot inhibitor D3 (5 μM; 45 minutes; PC12 cells;) significantly blocks NGF-induced dephosphorylation of cofilin at 15 and 30 minutes. Slingshot inhibitor D3 (5 μM; 45 minutes; PC12 cells) significantly decreases the NGF-induced cell migration, consistent with its inhibitory role in cofilin dephosphorylation. Slingshot inhibitor D3 (HEK293 cells) specifically blocks angiotensin II-induced cofilin dephosphorylation. Slingshot inhibitor D3 prevents cofilin dephosphroylation through inhibition of Slingshot. |
别名 | JHN76359 |
分子量 | 461.55 |
分子式 | C25H19NO4S2 |
CAS No. | 1715076-35-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 23.08 mg/mL (50 mM), Sonication and heating to 60℃ are recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.1666 mL | 10.8331 mL | 21.6661 mL | 54.1653 mL |
5 mM | 0.4333 mL | 2.1666 mL | 4.3332 mL | 10.8331 mL | |
10 mM | 0.2167 mL | 1.0833 mL | 2.1666 mL | 5.4165 mL | |
20 mM | 0.1083 mL | 0.5417 mL | 1.0833 mL | 2.7083 mL | |
50 mM | 0.0433 mL | 0.2167 mL | 0.4333 mL | 1.0833 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Slingshot inhibitor D3 1715076-35-9 Others Inhibitor competitive PC12 reversible selective Slingshot inhibitor D-3 HEK293 JHN76359 JHN 76359 Slingshot inhibitor D 3 JHN-76359 potent inhibit inhibitor