Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SGC-CK2-1 is an ATP-competitive chemical compound that acts as a highly potent and cell-active CK2 inhibitor. It demonstrates excellent selectivity towards both isoforms of human CK2, with IC50 values of 36 nM for CK2α and 16 nM for CK2α′ in the nanoBRET assay. Given its properties, SGC-CK2-1 is a suitable tool for the investigation of neurodegenerative diseases.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 495 | 5日内发货 | ||
5 mg | ¥ 828 | 5日内发货 | ||
1 mL * 10 mM (in DMSO) | ¥ 913 | 5日内发货 |
产品描述 | SGC-CK2-1 is an ATP-competitive chemical compound that acts as a highly potent and cell-active CK2 inhibitor. It demonstrates excellent selectivity towards both isoforms of human CK2, with IC50 values of 36 nM for CK2α and 16 nM for CK2α′ in the nanoBRET assay. Given its properties, SGC-CK2-1 is a suitable tool for the investigation of neurodegenerative diseases. |
靶点活性 | CK2α:36 nM (IC50), CK2α':16 nM (IC50) |
体外活性 | SGC-CK2-1 inhibits CSNK2A2 and CSNK2A1 with IC 50 s?value of 2.3 and 4.2 nM[1]. SGC-CK2-1 inhibits DYRK2 with the IC 50 value of 3.7 μM[1]. SGC-CK2-1 inhibits blood U-937, MV4-11, MOLM-13, OCI-LY19, OCI-AML5 cells with IC 50 s of 120, 690, 750, 760 and 810 nM, respectively. SGC-CK2-1 inhibits Head/Neck Detroit562 cells with an IC 50 of 550 nM. SGC-CK2-1 inhibits Lung NCI-H2286 cells with an IC 50 of 550 nM. SGC-CK2-1 inhibits Brain SK-N-MC cells with an IC 50 of 730 nM. SGC-CK2-1 inhibits Breast BT-20 cells with an IC 50 of 810 nM. SGC-CK2-1 inhibits Skin A375 cells with an IC 50 of 830 nM. SGC-CK2-1 inhibits Stomach SNU-1 cells with an IC 50 of 860 nM. SGC-CK2-1 inhibits Duodenum Hutu 80 cells with an IC 50 of 920 nM[1]. |
别名 | SGC-CK2-1 |
分子量 | 375.436 |
分子式 | C20H21N7O |
CAS No. | 2470424-39-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
SGC-CK2-1 2470424-39-4 SGC-CK-2-1 SGCCK21 SGC CK2 1 Inhibitor inhibitor inhibit