Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Robenacoxib (Onsior) 是一种对环氧化酶-2 有很强的选择性的非甾体化合物,具有抗炎活性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,590 | 现货 | ||
5 mg | ¥ 3,730 | 现货 | ||
10 mg | ¥ 4,970 | 现货 | ||
25 mg | ¥ 8,250 | 现货 | ||
50 mg | ¥ 10,900 | 现货 | ||
100 mg | ¥ 14,800 | 现货 |
产品描述 | Robenacoxib (Onsior) is a non-steroidal compound with strong selectivity for cyclooxygenase-2 and anti-inflammatory activity. |
体内活性 | Robenacoxib (2 mg/kg; oral; dogs) by oral (tablet) administration was effective and well tolerated in the control of peri-operative pain and inflammation associated with soft tissue surgery in dogs. Significantly (P = 0.019) more dogs administered Robenacoxib were considered treatment successes (89 of 116, 76.72%) compared to dogs given a placebo (74 of 115, 64.35%). The percentage of treatment failure was therefore 23.28% in the Robenacoxib and 35.65% in the placebo group. The least squares mean total pain scores were significantly different between groups and in favor of Robenacoxib at 3 and 5 hours (P < 0.05) and 8 hours post-extubation (P < 0.01). Pain at the surgery sites (response to touch) was also significantly improved at 3, 5, and 8 hours post-extubation in dogs receiving Robenacoxib versus placebo (P < 0.01). In addition, a significant overall improvement in posture/activity was revealed with Robenacoxib having lower scores versus placebo (P < 0.01). No significant differences between the Robenacoxib and placebo groups in the frequency of reported adverse events were observed.[2] |
别名 | Onsior |
分子量 | 327.27 |
分子式 | C16H13F4NO2 |
CAS No. | 220991-32-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (137.5 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.0556 mL | 15.2779 mL | 30.5558 mL | 76.3895 mL |
5 mM | 0.6111 mL | 3.0556 mL | 6.1112 mL | 15.2779 mL | |
10 mM | 0.3056 mL | 1.5278 mL | 3.0556 mL | 7.639 mL | |
20 mM | 0.1528 mL | 0.7639 mL | 1.5278 mL | 3.8195 mL | |
50 mM | 0.0611 mL | 0.3056 mL | 0.6111 mL | 1.5278 mL | |
100 mM | 0.0306 mL | 0.1528 mL | 0.3056 mL | 0.7639 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Robenacoxib 220991-32-2 Immunology/Inflammation Neuroscience COX Onsior Inhibitor inhibitor inhibit