keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
RGD (RGD (Arg-Gly-Asp) Peptides) 是一种细胞粘附基序,可以模拟细胞粘附蛋白并与整合素结合。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 213 | 现货 | ||
2 mg | ¥ 296 | 现货 | ||
5 mg | ¥ 533 | 现货 | ||
10 mg | ¥ 960 | 现货 | ||
25 mg | ¥ 1,500 | 现货 | ||
50 mg | ¥ 2,700 | 现货 | ||
100 mg | ¥ 3,950 | 现货 |
产品描述 | RGD (RGD (Arg-Gly-Asp) Peptides) (Arg-Gly-Asp) Peptides is a cell adhesion motif which can mimic cell adhesion proteins and bind to integrins. |
体外活性 | The RGD sequence is the cell attachment site of a large number of adhesive extracellular matrix, blood, and cell surface proteins, and nearly half of the over 20 known integrins recognize this sequence in their adhesion protein ligands. The RGD peptides and mimics can be used to probe integrin functions in various biological systems. Drug design based on the RGD structure may provide new treatments for diseases such as thrombosis, osteoporosis, and cancer. [1] RGD peptide acts as an inhibitor of integrin-ligand interactions and can induce apoptosis in the absence of signals and integrin-mediated cell clustering. Research demonstrates that RGD peptides promote apoptosis through activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing. [2] The RGD peptide can serve as a cell adhesion site of extracellular matrix, cell surface proteins, and integrins. [3] In addition, RGD peptide can inhibit ACK-2 activation through cell adhesion. [4] |
别名 | RGD (Arg-Gly-Asp) Peptides, Arg-Gly-Asp, RGD Peptides |
分子量 | 346.34 |
分子式 | C12H22N6O6 |
CAS No. | 99896-85-2 |
keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 34.6 mM
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O | 1 mM | 2.8873 mL | 14.4367 mL | 28.8734 mL | 72.1834 mL |
5 mM | 0.5775 mL | 2.8873 mL | 5.7747 mL | 14.4367 mL | |
10 mM | 0.2887 mL | 1.4437 mL | 2.8873 mL | 7.2183 mL | |
20 mM | 0.1444 mL | 0.7218 mL | 1.4437 mL | 3.6092 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
RGD 99896-85-2 Cytoskeletal Signaling Integrin RGD (Arg-Gly-Asp) Peptides inhibit Inhibitor Arg-Gly-Asp RGD Peptides inhibitor