Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Resmetirom (VIA-3196) 是一种高度选择性的THR-β激动剂(EC50:0.21 μM)。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 343 | 现货 | ||
2 mg | ¥ 497 | 现货 | ||
5 mg | ¥ 913 | 现货 | ||
10 mg | ¥ 1,330 | 现货 | ||
25 mg | ¥ 2,320 | 现货 | ||
50 mg | ¥ 3,630 | 现货 | ||
100 mg | ¥ 5,230 | 待询 | ||
500 mg | ¥ 10,900 | 待询 | ||
1 mL * 10 mM (in DMSO) | ¥ 873 | 现货 |
产品描述 | Resmetirom (VIA-3196) is a highly selective thyroid hormone receptor β (THR-β) agonist. |
靶点活性 | THRβ:0.21 μM(EC50) |
体外活性 | MGL-3196 is 28-fold selective for THR-β (EC50=0.21 μM) over THR-α (EC50=3.74 μM ) in a functional assay. MGL-3196 shows an IC20 of roughly 30 μM for blockage of the hERG channel. The IC50 for CYP3A4/5 and for CYP2C19 is >50 μM, and there is only weak inhibition (roughly 22 μM) of CYP2C9[1]. |
体内活性 | MGL-3196 exhibits good exposures and reasonable oral bioavailability in rats. The volume of distribution and clearance are both low. Dose proportional increases in exposure are observed for a suspension of MGL-3196 given orally to DIO mice[1].In animals treated with MGL-3196 there is a reduction in cholesterol and in liver size, which is secondary to reduction of liver TG. There is no effect on bone mineral density (BMD) or heart or kidney size in MGL-3196 treated animals[1]. |
别名 | VIA-3196, MGL3196 |
分子量 | 435.22 |
分子式 | C17H12Cl2N6O4 |
CAS No. | 920509-32-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/mL (137.86 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.2977 mL | 11.4884 mL | 22.9769 mL | 57.4422 mL |
5 mM | 0.4595 mL | 2.2977 mL | 4.5954 mL | 11.4884 mL | |
10 mM | 0.2298 mL | 1.1488 mL | 2.2977 mL | 5.7442 mL | |
20 mM | 0.1149 mL | 0.5744 mL | 1.1488 mL | 2.8721 mL | |
50 mM | 0.046 mL | 0.2298 mL | 0.4595 mL | 1.1488 mL | |
100 mM | 0.023 mL | 0.1149 mL | 0.2298 mL | 0.5744 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Resmetirom 920509-32-6 Endocrinology/Hormones Thyroid hormone receptor(THR) VIA-3196 Inhibitor MGL-3196 Thyroid Hormone Receptor MGL 3196 VIA 3196 THR inhibit VIA3196 MGL3196 inhibitor