Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Pyoluteorin 是一种抗生素 (antibiotic),可抑制 Oomycete fungi,包括植物病原体 Oomycete fungi,并抑制由该真菌引起的植物病害。 Pyoluteorin 在体外诱导人三阴性乳腺癌 MDA-MB-231 细胞凋亡 (apoptosis)。 Pyoluteorin 可用于人类三阴性乳腺癌的研究。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,510 | 现货 | ||
5 mg | ¥ 3,490 | 现货 | ||
10 mg | ¥ 4,960 | 现货 | ||
25 mg | ¥ 7,920 | 现货 | ||
50 mg | ¥ 10,600 | 现货 | ||
100 mg | ¥ 14,300 | 现货 | ||
500 mg | ¥ 28,800 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 2,990 | 现货 |
产品描述 | Pyoluteorin is an antibiotic that inhibits Oomycete fungi, including the plant pathogen Pythium ultimum, and suppresses plant diseases caused by this fungus. Pyoluteorin induces human triple-negative breast cancer MDA-MB-231 cells apoptosis in vitro. |
体外活性 | Pyoluteorin is an antifungal compound composed of a bichlorinated pyrrole linked to a resorcinol moiety, were identified within a 24-kb genomic region of Pseudomonas fluorescens Pf-5[1]. Pyoluteorin has significant cytotoxicity towards MCF-7 (IC50=1.84 μM). Pyoluteorin also displays significantly selective cytotoxicity against BT474, HCC1954, MAD-MB-468, MDA-MB-231, and MCF-10A cells with IC50 values of 9.75±0.16, 0.94±0.01, 3.89±0.08, 0.97±0.01, and 57.01±0.76 μM, respectively[2]. Pyoluteorin (0.1-10 μM; for 24 hours) induces change of apoptosis-related protein expressions. Pyoluteorin-induced cell apoptosis in MDA-MB-231 is related to Bcl-2 family proteins and caspase cascade[2]. Pyoluteorin (0.1-10 μM; for 24 h) induces cell cycle arrest and apoptosis in human triple-negative breast cancer cells MDA-MB-231[2]. |
分子量 | 272.08 |
分子式 | C11H7Cl2NO3 |
CAS No. | 25683-07-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (202.15 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.6754 mL | 18.3769 mL | 36.7539 mL | 91.8847 mL |
5 mM | 0.7351 mL | 3.6754 mL | 7.3508 mL | 18.3769 mL | |
10 mM | 0.3675 mL | 1.8377 mL | 3.6754 mL | 9.1885 mL | |
20 mM | 0.1838 mL | 0.9188 mL | 1.8377 mL | 4.5942 mL | |
50 mM | 0.0735 mL | 0.3675 mL | 0.7351 mL | 1.8377 mL | |
100 mM | 0.0368 mL | 0.1838 mL | 0.3675 mL | 0.9188 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Pyoluteorin 25683-07-2 Microbiology/Virology Antibiotic Inhibitor inhibitor inhibit