Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PF-04217903 methanesulfonate is a potent ATP-competitive inhibitor of c-Met kinase (Ki of 4.8 nM for human c-Met).
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 374 | 5日内发货 | ||
5 mg | ¥ 622 | 5日内发货 | ||
10 mg | ¥ 1,090 | 5日内发货 | ||
1 mL * 10 mM (in DMSO) | ¥ 683 | 5日内发货 |
PF-04217903 methanesulfonate 的其他形式现货产品:
产品描述 | PF-04217903 methanesulfonate is a potent ATP-competitive inhibitor of c-Met kinase (Ki of 4.8 nM for human c-Met). |
靶点活性 | c-Met (human):ki:4.8 nM |
体外活性 | PF-04217903 induces apoptosis of GTL-16 cells (IC50=31 nM) [1]. PF-04217903 methanesulfonate also inhibits HGF-mediated cell migration and Matrigel invasion in several c-Met–overexpressing tumor cell lines such as human NCI-H441 lung carcinoma and HT29 colon carcinoma with IC50 values comparable with those for inhibition of c-Met phosphorylation in these cell lines (IC50= 7-12.5 nM)[1]. |
体内活性 | PF-04217903 methanesulfonate shows a significant dose-dependent reduction of human IL-8 levels in both the U87MG and GTL-16 models and decreases human VEGFA levels in the GTL-16 model. PF-04217903 methanesulfonate strongly induces phospho-PDGFRβ levels in U87MG xenograft tumors[1]. |
分子量 | 468.49 |
分子式 | C20H20N8O4S |
CAS No. | 956906-93-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (106.73 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.1345 mL | 10.6726 mL | 21.3452 mL | 53.3629 mL |
5 mM | 0.4269 mL | 2.1345 mL | 4.269 mL | 10.6726 mL | |
10 mM | 0.2135 mL | 1.0673 mL | 2.1345 mL | 5.3363 mL | |
20 mM | 0.1067 mL | 0.5336 mL | 1.0673 mL | 2.6681 mL | |
50 mM | 0.0427 mL | 0.2135 mL | 0.4269 mL | 1.0673 mL | |
100 mM | 0.0213 mL | 0.1067 mL | 0.2135 mL | 0.5336 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
PF-04217903 methanesulfonate 956906-93-7 Tyrosine Kinase/Adaptors c-Met/HGFR PF04217903 methanesulfonate PF 04217903 methanesulfonate Inhibitor inhibitor inhibit