Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PB2, a tris(2-carboxyethyl)phosphine (TCEP) analogue, enhances the survival of retinal ganglion cells (RGCs) following axotomy in vitro. Even at nanomolar and picomolar concentrations, PB2 demonstrates pronounced efficacy in promoting RGC survival. Notably, PB2 exhibits superior permeability compared to TCEP. Serving as a potent reducing agent, PB2 provides robust neuroprotection for RGCs[1].
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 984 | 5日内发货 | ||
5 mg | ¥ 1,660 | 5日内发货 | ||
10 mg | ¥ 2,890 | 5日内发货 | ||
25 mg | ¥ 5,940 | 5日内发货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,830 | 5日内发货 |
产品描述 | PB2, a tris(2-carboxyethyl)phosphine (TCEP) analogue, enhances the survival of retinal ganglion cells (RGCs) following axotomy in vitro. Even at nanomolar and picomolar concentrations, PB2 demonstrates pronounced efficacy in promoting RGC survival. Notably, PB2 exhibits superior permeability compared to TCEP. Serving as a potent reducing agent, PB2 provides robust neuroprotection for RGCs[1]. |
体外活性 | PB2 (0.001~100000 nM; 72 hours; RGCs) increases RGC viability[1].PB2 has modifications that neutralize the polarity of the compounds. The methylesters of PB2 is likely to be cleaved by cytosolic esterases, yielding a polar intracellular intermediate that would be unlikely to cross cell membranes[1]. |
分子量 | 286.12 |
分子式 | C16H20BO2P |
CAS No. | 914940-24-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (349.52 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.495 mL | 17.4752 mL | 34.9504 mL | 87.3759 mL |
5 mM | 0.699 mL | 3.495 mL | 6.9901 mL | 17.4752 mL | |
10 mM | 0.3495 mL | 1.7475 mL | 3.495 mL | 8.7376 mL | |
20 mM | 0.1748 mL | 0.8738 mL | 1.7475 mL | 4.3688 mL | |
50 mM | 0.0699 mL | 0.3495 mL | 0.699 mL | 1.7475 mL | |
100 mM | 0.035 mL | 0.1748 mL | 0.3495 mL | 0.8738 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
PB2 914940-24-2 PB 2 PB-2 Inhibitor inhibitor inhibit