Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Pallidol is a potent and selective singlet oxygen quencher in aqueous systems, it may be used in singlet oxygen-mediated diseases as a pharmacological agent.
产品描述 | Pallidol is a potent and selective singlet oxygen quencher in aqueous systems, it may be used in singlet oxygen-mediated diseases as a pharmacological agent. |
体外活性 | Pallidol is a naturally occurring resveratrol dimer from red wine with antioxidant and antifungal activities. METHODS AND RESULTS:In this report, with the use of the EPR spin-trapping technique, the scavenging and quenching effects of Pallidol on reactive oxygen species (ROS) were investigated. The results demonstrated that Pallidol showed strong quenching effects on singlet oxygen at very low concentrations, but it was ineffective to scavenge hydroxyl radicals or superoxide anions. Further kinetic study revealed that the reaction of Pallidol with singlet oxygen had an extremely high rate constant (k(a)=1.71x10(10)). CONCLUSIONS:Therefore, Pallidol is a potent and selective singlet oxygen quencher in aqueous systems. It may be used in singlet oxygen-mediated diseases as a pharmacological agent, which may contribute to the health beneficial effects of red wine. |
分子量 | 454.48 |
分子式 | C28H22O6 |
CAS No. | 105037-88-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
中药材名称 | 中药材拉丁名 | 性 | 味 | 归经 |
金雀根 | Caragana sinica(Buchoz)Rehd. | 平 | 苦, 辛 | 肺, 脾 |
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请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
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体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
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Pallidol 105037-88-5 Inhibitor inhibitor inhibit