Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Norepinephrine hydrochloride (Levarterenol hydrochloride) 是一种β1选择性的肾上腺素受体激动剂,EC50值为 5.37 μM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
10 mg | ¥ 106 | 6-8周 | ||
25 mg | ¥ 147 | 6-8周 |
Norepinephrine hydrochloride 的其他形式现货产品:
产品描述 | Norepinephrine hydrochloride (Levarterenol hydrochloride) is a β1 -selective agonist of the adrenergic receptor with EC 50 of 5.37 μM [1]. |
体外活性 | Norepinephrine (NE) bitartrate monohydrate is generally considered to be a β 1 -subtype selective adrenergic agonist. Norepinephrine(NE) also shows direct activity at the β 2 -adrenoceptor in higher concentrations [1]. Adipocytes from the inguinal fat pad (iWA) or the interscapular fat pad (BA) are isolated from neonatal wild-type C57BL/6J mice and cultured. To examine the effect of activating AT2 upon β-adrenergic signaling, cAMP production is first assessed in response to Norepinephrine (NE, 10 μM) with or without CGP (10 nM) co-treatment. Norepinephrine (NE) increases cAMP as expected in iWA, and CGP does not alter this effect. Norepinephrine (NE) is also known to induce lipolysis, and liberated fatty acids are required to functionally activate UCP1 protein and to stimulate heat production. CREB phosphorylation at Ser133 is increased after Norepinephrine (NE) treatment and significantly reduced with CGP co-treatment in mouse iWA [2]. |
分子量 | 205.64 |
分子式 | C8H12ClNO3 |
CAS No. | 329-56-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Norepinephrine hydrochloride 329-56-6 Inhibitor inhibitor inhibit