Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Nedocromil sodium is a pharmacologic stabilizer of mast cells, has been shown to normalize cytokine levels and attenuate cardiac remodeling.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 770 | 35日内发货 | ||
10 mg | ¥ 1,470 | 35日内发货 | ||
25 mg | ¥ 3,370 | 35日内发货 | ||
50 mg | ¥ 5,610 | 35日内发货 |
Nedocromil sodium 的其他形式现货产品:
产品描述 | Nedocromil sodium is a pharmacologic stabilizer of mast cells, has been shown to normalize cytokine levels and attenuate cardiac remodeling. |
体外活性 | Nedocromil treatment halted contractile dysfunction in diabetic mice and reduced cardiac mast cell density, which correlated with reduced bioactive enzyme secretions, reduced expression of extracellular matrix remodeling factors and collagen synthesis, and normalized cytokine levels.Nedocromil inhibits the release of histamine, LTC4, and PGD2 from mast cells challenged with antigen (with IC30 values of 2.1 μM, 2.3 μM, and 1.9 μM, respectively) and with anti-human IgE (IC30 values of 4.7 μM, 1.3 μM, and 1.3 μM, respectively)[1]. |
体内活性 | Treated the diabetic mice with nedocromil for 12 weeks and then examined their hearts for signs of cardiac remodeling and quantified contractile function.?We observed significantly impaired heart function in diabetic mice, as well as increased cardiac mast cell density and elevated mast cell secretions that correlated with gene expression and aberrant cytokine levels associated with cardiac remodeling. |
别名 | Nedocromil disodium salt, FPL 59002KP |
分子量 | 394.335 |
分子式 | C19H17NNaO7 |
CAS No. | 69049-74-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 5.2 mg/mL (12.52 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.5359 mL | 12.6796 mL | 25.3591 mL | 63.3979 mL |
5 mM | 0.5072 mL | 2.5359 mL | 5.0718 mL | 12.6796 mL | |
10 mM | 0.2536 mL | 1.268 mL | 2.5359 mL | 6.3398 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Nedocromil sodium 69049-74-7 Others Nedocromil Nedocromil disodium Nedocromil disodium salt FPL 59002KP Inhibitor inhibitor inhibit