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Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat

产品编号 T7657 CAS 149635-73-4

别名: 髓鞘少突胶质细胞糖蛋白, MOG (35-55)

Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat (MOG (35-55)) 是中枢神经鞘的一个次要成分。它能诱导强效的 T 细胞和 B 细胞反应，同时是高度脑源性的。它能够引发复发缓解性神经系统疾病，伴有广泛的斑块样脱髓鞘。

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Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat Chemical Structure

Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat, CAS 149635-73-4

规格	价格/CNY	货期
1 mg	￥ 579	现货
2 mg	￥ 886	现货
5 mg	￥ 1,570	现货
10 mg	￥ 2,530	现货
25 mg	￥ 4,170	现货
50 mg	￥ 5,930	现货

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其他形式的 Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat:

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纯度: 93.16%

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生物活性

化学信息

存储 & 溶解度

参考文献

产品描述	Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat (MOG (35-55)) is a truncated peptide derived from the human Myelin Oligodendrocyte Glycoprotein (MOG).
体外活性	CD8CD3 and CD4CD3 cells were 86% and 94% pure of total CD3 cells after CD8/CD4 bead enrichment, respectively.?These cells were stimulated by MOG35-55 peptide and applied to proliferation assays.?Although the CD8 T cells had a generally lower response to MOG35-55 than CD4 T cells, the response of CD8 T cells was not always dependent on CD4.?CD8 T cell secreted less IFN-γ and IL-4 compared with CD4 T cells[1].
体内活性	EAE was induced in wildtype B6 na?ve mice by adoptive transfer of MOG35-55-specific T cells from B6 active-induced EAE (aEAE) mice.?A similar EAE score and slight inflammation and demyelination were found in naive B6 mice after transferring of CD8 T cells from immunized B6 mice compared with transfer of CD4 T cells[1].
动物实验	Female C57BL/6 mice (n?=?20) were induced by myelin oligodendrocyte glycoprotein (MOG)35-55 peptide.?At 14 days after immunization, T cells were isolated from the spleen and purified as CD4 and CD8 T cells by using CD4 and CD8 isolation kits, and then the purity was determined by flow cytometric analysis.?These cells were stimulated by MOG35-55 peptide and applied to proliferation assays.?The interferon-gamma (IFN-γ) and interleukin (IL)-4 secretion of supernatant of cultured CD4 and CD8 T cells were measured by enzyme-linked immunosorbent assays (ELISA).?For adoptive transfer, recipient mice were injected with MOG35-55-specific CD8 or CD4 T cells.?EAE clinical course was measured by EAE score at 0-5 scale and spinal cord was examined by staining with hematoxylin and eosin and Luxol fast blue staining[1].

别名	髓鞘少突胶质细胞糖蛋白, MOG (35-55)
分子量	2581.95
分子式	C118H177N35O29S
CAS No.	149635-73-4

存储

keep away from moisture　|　Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

H2O: Insoluble

DMSO: Insoluble

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参考文献

1. Peng Y, Zhu FZ, Chen ZX,et al.Characterization of myelin oligodendrocyte glycoprotein (MOG)35-55-specific CD8+ T cells in experimental autoimmune encephalomyelitis[J].Chin Med J (Engl). 2019 Dec 20;132(24):2934-2940. 2. Ichikawa M , , Johns T G , Liu J , , et al. Analysis of the fine B cell specificity during the chronic/relapsing course of a multiple sclerosis-like disease in Lewis rats injected with the encephalitogenic myelin oligodendrocyte glycoprotein peptide 35-55[J]. Journal of Immunology, 1996, 157(2):919.

剂量换算

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体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

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