Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ML228 是一种有效的 HIF 信号通路激活剂,EC50 为 1 μM。ML228 可激活 HIF 以及下游 EGFR。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 352 | 现货 | ||
5 mg | ¥ 798 | 现货 | ||
10 mg | ¥ 1,430 | 现货 | ||
25 mg | ¥ 2,970 | 现货 | ||
50 mg | ¥ 4,390 | 现货 | ||
100 mg | ¥ 6,260 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 885 | 现货 |
产品描述 | ML228 is a potent the Hypoxia Inducible Factor (HIF) pathway activator with EC50 of 1 μM. ML228 potently activates HIF in vitro as well as its downstream target VEGF. |
体外活性 | ML228 represents a novel chemotype available to the research community for the study of HIF activation and its therapeutic potential. Not only is the compound substantially different in structure from known HIF activators, ML228 lacks the acidic functional group almost universally present in PHD inhibitors, which may be important for certain disease applications[1][2]. |
体内活性 | ML228 (injection; 1 µg/kg; 7 days) treatments following spinal cord injury (SCI) improves the local hypoxic ischemia environment, reduces SCI secondary injury and promotes the recovery of neurological function[3]. |
分子量 | 415.49 |
分子式 | C27H21N5 |
CAS No. | 1357171-62-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (72.2 mM), Sonification is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.4068 mL | 12.034 mL | 24.068 mL | 60.1699 mL |
5 mM | 0.4814 mL | 2.4068 mL | 4.8136 mL | 12.034 mL | |
10 mM | 0.2407 mL | 1.2034 mL | 2.4068 mL | 6.017 mL | |
20 mM | 0.1203 mL | 0.6017 mL | 1.2034 mL | 3.0085 mL | |
50 mM | 0.0481 mL | 0.2407 mL | 0.4814 mL | 1.2034 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
ML228 1357171-62-0 Angiogenesis Chromatin/Epigenetic HIF ML 228 ML-228 Inhibitor inhibitor inhibit