Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Mivacurium dichloride (Mivacurium chloride) 是苄基异喹啉衍生物,可与 nAChR 偶联,以减少或抑制乙酰胆碱对肌肉细胞末端盘的去极化作用。它也是非去极化短效的神经肌肉阻滞剂和骨骼肌松弛剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 354 | 现货 | ||
5 mg | ¥ 567 | 现货 | ||
10 mg | ¥ 823 | 现货 | ||
25 mg | ¥ 1,197 | 现货 | ||
50 mg | ¥ 1,887 | 现货 | ||
100 mg | ¥ 2,961 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 938 | 现货 |
产品描述 | Mivacurium dichloride (Mivacurium chloride) is a non-depolarising, rapid neuromuscular blocker of short duration, used therefore as anesthetic, to provide skeletal muscle relaxation in minor surgical operations, in emergency surgical procedures of short to intermediate duration and during intubation of the trachea. |
体外活性 | Mivacurium caused pseudo-allergic reactions in wild-type mice by inducing mast cells to release histamine.?However, it did not induce a similar phenomenon in KitW-sh/W-sh mice.?Furthermore, MrgprB2-knockout mice displayed no inflammatory response to mivacurium.?Mivacurium induced LAD2 cell degranulation in a dose-dependent manner.?Mivacurium stimulated intracellular calcium ion (Ca2+) influx in MRGPRX2-HEK293 cells but not in NC-HEK293 cells.?However, mivacurium induced the release of only low levels of mediators in LAD2 cells transfected with MRGPRX2-targeted small interfering (si)RNA.?Notably, cytokine release was not observed in LAD2 cells even when stimulated with high concentrations of mivacurium[1]. |
体内活性 | Mivacurium is rapidly hydrolyzed in the plasma with a short duration of action(< 10 min). Mivacurium has lots of advantages, like a rapid effect, nonneurological toxicity and a lack of heart rate alteration. Mivacurium causes pseudo-allergic reactions in C57 wild-type mice by inducing mast cells to release histamine and a decrease in body temperature[1]. |
别名 | 米库氯铵, Mivacurium chloride, 二氯美维库铵 |
分子量 | 1100.17 |
分子式 | C58H80Cl2N2O14 |
CAS No. | 106861-44-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 100 mg/ml (90.9 mM)
DMSO: 100 mg/ml (90.9 mM)
H2O: 100 mg/ml (90.9 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
Ethanol / DMSO / H2O | 1 mM | 0.909 mL | 4.5448 mL | 9.0895 mL | 22.7238 mL |
5 mM | 0.1818 mL | 0.909 mL | 1.8179 mL | 4.5448 mL | |
10 mM | 0.0909 mL | 0.4545 mL | 0.909 mL | 2.2724 mL | |
20 mM | 0.0454 mL | 0.2272 mL | 0.4545 mL | 1.1362 mL | |
50 mM | 0.0182 mL | 0.0909 mL | 0.1818 mL | 0.4545 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
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